John C H Spence
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Explore the profile of John C H Spence including associated specialties, affiliations and a list of published articles.
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104
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4234
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Recent Articles
1.
Zhuang Y, Awel S, Barty A, Bean R, Bielecki J, Bergemann M, et al.
IUCrJ
. 2022 Apr;
9(Pt 2):204-214.
PMID: 35371510
One of the outstanding analytical problems in X-ray single-particle imaging (SPI) is the classification of structural heterogeneity, which is especially difficult given the low signal-to-noise ratios of individual patterns and...
2.
Doppler D, Rabbani M, Letrun R, Cruz Villarreal J, Kim D, Gandhi S, et al.
J Appl Crystallogr
. 2022 Feb;
55(Pt 1):1-13.
PMID: 35153640
Serial femtosecond crystallography (SFX) is a powerful technique that exploits X-ray free-electron lasers to determine the structure of macro-molecules at room temperature. Despite the impressive exposition of structural details with...
3.
Pandey S, Calvey G, Katz A, Malla T, Koua F, Martin-Garcia J, et al.
IUCrJ
. 2021 Nov;
8(Pt 6):878-895.
PMID: 34804542
Here, we illustrate what happens inside the catalytic cleft of an enzyme when substrate or ligand binds on single-millisecond timescales. The initial phase of the enzymatic cycle is observed with...
4.
Spence J, Donatelli J
Ultramicroscopy
. 2021 Nov;
231:113409.
PMID: 34756481
A method for recovering complex structure factors from many simultaneously excited Bragg beam in- tensities is described. The method is applied to simulated transmission electron diffraction data over a wide...
5.
Yun J, Li X, Yue J, Park J, Jin Z, Li C, et al.
Proc Natl Acad Sci U S A
. 2021 Mar;
118(13).
PMID: 33753488
Chloride ion-pumping rhodopsin (ClR) in some marine bacteria utilizes light energy to actively transport Cl into cells. How the ClR initiates the transport is elusive. Here, we show the dynamics...
6.
Ramakrishnan S, Stagno J, Conrad C, Ding J, Yu P, Bhandari Y, et al.
Nat Commun
. 2021 Mar;
12(1):1762.
PMID: 33741910
Time-resolved studies of biomacromolecular crystals have been limited to systems involving only minute conformational changes within the same lattice. Ligand-induced changes greater than several angstroms, however, are likely to result...
7.
Spence J, Donatelli J
Ultramicroscopy
. 2021 Feb;
222:113214.
PMID: 33561601
A method for recovering complex structure factors from many simultaneously excited Bragg beam in- tensities is described. The method is applied to simulated transmission electron diffraction data over a wide...
8.
Echelmeier A, Cruz Villarreal J, Messerschmidt M, Kim D, Coe J, Thifault D, et al.
Nat Commun
. 2020 Sep;
11(1):4511.
PMID: 32908128
Serial femtosecond crystallography (SFX) with X-ray free electron lasers (XFELs) allows structure determination of membrane proteins and time-resolved crystallography. Common liquid sample delivery continuously jets the protein crystal suspension into...
9.
Donatelli J, Spence J
Phys Rev Lett
. 2020 Aug;
125(6):065502.
PMID: 32845656
An iterated projection algorithm (N-Phaser) is developed that reconstructs a scattering potential from N-beam multiple Bragg scattered intensities. The method may be used to eliminate multiple scattering artifacts from electron...
10.
Nazari R, Zaare S, Alvarez R, Karpos K, Engelman T, Madsen C, et al.
Opt Express
. 2020 Aug;
28(15):21749-21765.
PMID: 32752448
Gas dynamic virtual nozzles (GDVNs) produce microscopic flow-focused liquid jets and droplets and play an important role at X-ray free-electron laser (XFEL) facilities where they are used to steer a...