Sebastien Boutet
Overview
Explore the profile of Sebastien Boutet including associated specialties, affiliations and a list of published articles.
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Articles
140
Citations
6113
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Recent Articles
1.
Revealing the reaction path of UVC bond rupture in cyclic disulfides with ultrafast x-ray scattering
Ma L, Du W, Yong H, Stankus B, Ruddock J, Carrascosa A, et al.
Sci Adv
. 2025 Jan;
11(3):eadp9175.
PMID: 39813348
Disulfide bonds are ubiquitous molecular motifs that influence the tertiary structure and biological functions of many proteins. Yet, it is well known that the disulfide bond is photolabile when exposed...
2.
Fletcher L, Levitan A, McBride E, Kim J, Alves E, Aquila A, et al.
Sci Rep
. 2024 Jul;
14(1):17283.
PMID: 39068229
We report time resolved observations of the crystallization from liquid hydrogen, supercooled to temperatures below the melting point, using 11.2 keV X-ray diffraction from the Linac Coherent Light Source (LCLS)....
3.
Griffiths J, Suzana A, Wu L, Marks S, Esposito V, Boutet S, et al.
Nat Mater
. 2024 Jul;
23(8):1150.
PMID: 39009657
No abstract available.
4.
Griffiths J, Suzana A, Wu L, Marks S, Esposito V, Boutet S, et al.
Nat Mater
. 2024 Jun;
23(8):1041-1047.
PMID: 38871940
Material functionality can be strongly determined by structure extending only over nanoscale distances. The pair distribution function presents an opportunity for structural studies beyond idealized crystal models and to investigate...
5.
Smith N, Dasgupta M, Wych D, Dolamore C, Sierra R, Lisova S, et al.
Sci Adv
. 2024 Mar;
10(13):eadk7201.
PMID: 38536910
Enzymes populate ensembles of structures necessary for catalysis that are difficult to experimentally characterize. We use time-resolved mix-and-inject serial crystallography at an x-ray free electron laser to observe catalysis in...
6.
Ishigami I, Sierra R, Su Z, Peck A, Wang C, Poitevin F, et al.
Nat Commun
. 2023 Sep;
14(1):5752.
PMID: 37717031
Cytochrome c oxidase (CcO) is an essential enzyme in mitochondrial and bacterial respiration. It catalyzes the four-electron reduction of molecular oxygen to water and harnesses the chemical energy to translocate...
7.
Malla T, Zielinski K, Aldama L, Bajt S, Feliz D, Hayes B, et al.
Nat Commun
. 2023 Sep;
14(1):5507.
PMID: 37679343
For decades, researchers have elucidated essential enzymatic functions on the atomic length scale by tracing atomic positions in real-time. Our work builds on possibilities unleashed by mix-and-inject serial crystallography (MISC)...
8.
Smith N, Dasgupta M, Wych D, Dolamore C, Sierra R, Lisova S, et al.
bioRxiv
. 2023 Aug;
PMID: 37645800
Enzymes populate ensembles of structures with intrinsically different catalytic proficiencies that are difficult to experimentally characterize. We use time-resolved mix-and-inject serial crystallography (MISC) at an X-ray free electron laser (XFEL)...
9.
Kalita A, Mrozek-McCourt M, Kaldawi T, Willmott P, Loh N, Marte S, et al.
Nature
. 2023 Aug;
620(7974):557-561.
PMID: 37587300
Supercooled water droplets are widely used to study supercooled water, ice nucleation and droplet freezing. Their freezing in the atmosphere affects the dynamics and climate feedback of clouds and can...
10.
Hutchison C, Baxter J, Fitzpatrick A, Dorlhiac G, Fadini A, Perrett S, et al.
Nat Chem
. 2023 Aug;
15(11):1607-1615.
PMID: 37563326
The photoisomerization reaction of a fluorescent protein chromophore occurs on the ultrafast timescale. The structural dynamics that result from femtosecond optical excitation have contributions from vibrational and electronic processes and...