John Blazeck
Overview
Explore the profile of John Blazeck including associated specialties, affiliations and a list of published articles.
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23
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922
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Recent Articles
1.
Fox A, Blazeck J
Metab Eng
. 2024 Nov;
86:250-261.
PMID: 39490640
Chimeric antigen receptor (CAR) T cells are an engineered immunotherapy that express synthetic receptors to recognize and kill cancer cells. Despite their success in treating hematologic cancers, CAR T cells...
2.
Haikal Y, Blazeck J
Curr Opin Biomed Eng
. 2024 Oct;
31.
PMID: 39430298
The ability to precisely control cellular function in response to external stimuli can enhance the function and safety of cell therapies. In this review, we will detail how the modularity...
3.
Cox J, Fox A, Lenahan C, Pivnik L, Manion M, Blazeck J
Biotechnol J
. 2024 Feb;
19(2):e2300446.
PMID: 38403442
Accumulation of the ribonucleoside, adenosine (ADO), triggers a cAMP response element binding protein (CREB)-mediated signaling pathway to suppress the function of immune cells in tumors. Here, we describe a collection...
4.
Cazier A, Irvin O, Chavez L, Dalvi S, Abraham H, Wickramanayake N, et al.
ACS Synth Biol
. 2023 Oct;
12(11):3287-3300.
PMID: 37873982
The yeast is commonly used to interrogate and screen protein variants and to perform directed evolution studies to develop proteins with enhanced features. While several techniques have been described that...
5.
Jennings M, Min S, Xu G, Homayuni K, Suresh B, Haikal Y, et al.
Protein Expr Purif
. 2023 Sep;
213:106362.
PMID: 37683902
Homo sapiens adenosine deaminase isoform 1 (HsADA1) hydrolyzes adenosine and 2-deoxyadenosine as a key step in the purine nucleoside salvage pathway. Some HsADA1 mutations have severe deleterious effects, as is...
6.
Holland K, Blazeck J
J Biol Eng
. 2022 Dec;
16(1):37.
PMID: 36575525
The eukaryotic yeast Saccharomyces cerevisiae is a model host utilized for whole cell biocatalytic conversions, protein evolution, and scientific inquiries into the pathogenesis of human disease. Over the past decade,...
7.
Blazeck J, Karamitros C, Ford K, Somody C, Qerqez A, Murray K, et al.
Nat Catal
. 2022 Dec;
5(10):952-967.
PMID: 36465553
The Trp metabolite kynurenine (KYN) accumulates in numerous solid tumours and mediates potent immunosuppression. Bacterial kynureninases (KYNases), which preferentially degrade kynurenine, can relieve immunosuppression in multiple cancer models, but immunogenicity...
8.
Ma M, Jennings M, Blazeck J, Lieberman R
Acta Crystallogr D Struct Biol
. 2022 Jan;
78(Pt 1):91-103.
PMID: 34981765
Homo sapiens adenosine deaminase 1 (HsADA1; UniProt P00813) is an immunologically relevant enzyme with roles in T-cell activation and modulation of adenosine metabolism and signaling. Patients with genetic deficiency in...
9.
Jennings M, Munn D, Blazeck J
J Immunother Cancer
. 2021 Oct;
9(10).
PMID: 34667078
Tumors accumulate metabolites that deactivate infiltrating immune cells and polarize them toward anti-inflammatory phenotypes. We provide a comprehensive review of the complex networks orchestrated by several of the most potent...
10.
Cox J, Blazeck J
Trends Biotechnol
. 2021 Oct;
40(4):509-521.
PMID: 34627648
The full application of the diverse toolkit of protein engineering has made it easier to control the immune system. In particular, synthetic cytokine variants and engineered immune receptor platforms have...