John Blazeck
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Explore the profile of John Blazeck including associated specialties, affiliations and a list of published articles.
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23
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922
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Recent Articles
11.
Cazier A, Blazeck J
Biotechnol J
. 2021 Aug;
16(10):e2100239.
PMID: 34351706
Synthetic biology continues to progress by relying on more robust tools for transcriptional control, of which promoters are the most fundamental component. Numerous studies have sought to characterize promoter function,...
12.
Triplett T, Garrison K, Marshall N, Donkor M, Blazeck J, Lamb C, et al.
Nat Biotechnol
. 2018 Jul;
36(8):758-764.
PMID: 30010674
Increased tryptophan (Trp) catabolism in the tumor microenvironment (TME) can mediate immune suppression by upregulation of interferon (IFN)-γ-inducible indoleamine 2,3-dioxygenase (IDO1) and/or ectopic expression of the predominantly liver-restricted enzyme tryptophan...
13.
Blazeck J, Hill A, Jamoussi M, Pan A, Miller J, Alper H
Metab Eng
. 2015 Sep;
32:66-73.
PMID: 26384571
Itaconic acid is a naturally produced organic acid with diverse applications as a replacement for petroleum derived products. However, its industrial viability as a bio-replacement has been restricted due to...
14.
Liu L, Markham K, Blazeck J, Zhou N, Leon D, Otoupal P, et al.
Metab Eng
. 2015 Jul;
31:102-11.
PMID: 26219673
Lipogenic organisms represent great starting points for metabolic engineering of oleochemical production. While previous engineering efforts were able to significantly improve lipid production in Yarrowia lipolytica, the lipogenesis landscape, especially...
15.
Blazeck J, Miller J, Pan A, Gengler J, Holden C, Jamoussi M, et al.
Appl Microbiol Biotechnol
. 2014 Jul;
98(19):8155-64.
PMID: 24997118
Renewable alternatives for petroleum-derived chemicals are achievable through biosynthetic production. Here, we utilize Saccharomyces cerevisiae to enable the synthesis of itaconic acid, a molecule with diverse applications as a petrochemical...
16.
Blazeck J, Hill A, Liu L, Knight R, Miller J, Pan A, et al.
Nat Commun
. 2014 Jan;
5:3131.
PMID: 24445655
Economic feasibility of biosynthetic fuel and chemical production hinges upon harnessing metabolism to achieve high titre and yield. Here we report a thorough genotypic and phenotypic optimization of an oleaginous...
17.
Blazeck J, Liu L, Knight R, Alper H
J Biotechnol
. 2013 Apr;
165(3-4):184-94.
PMID: 23602802
The complete biosynthetic replacement of petroleum transportation fuels requires a metabolic pathway capable of producing short chain n-alkanes. Here, we report and characterize a proof-of-concept pathway that enables microbial production...
18.
Blazeck J, Reed B, Garg R, Gerstner R, Pan A, Agarwala V, et al.
Appl Microbiol Biotechnol
. 2012 Oct;
97(7):3037-52.
PMID: 23053080
Both varied and strong promoters are essential for metabolic and pathway engineering applications in any host organism. To enable this capacity, here we demonstrate a generalizable method for the de...
19.
Blazeck J, Alper H
Biotechnol J
. 2012 Aug;
8(1):46-58.
PMID: 22890821
Synthetic control of gene expression is critical for metabolic engineering efforts. Specifically, precise control of key pathway enzymes (heterologous or native) can help maximize product formation. The fundamental level of...
20.
Blazeck J, Garg R, Reed B, Alper H
Biotechnol Bioeng
. 2012 May;
109(11):2884-95.
PMID: 22565375
A dynamic range of well-controlled constitutive and tunable promoters are essential for metabolic engineering and synthetic biology applications in all host organisms. Here, we apply a synthetic hybrid promoter approach...