Johannes H Schulte
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Explore the profile of Johannes H Schulte including associated specialties, affiliations and a list of published articles.
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164
Citations
5603
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Recent Articles
11.
Sprussel A, Suzuki T, Miyata N, Astrahantseff K, Szymansky A, Toedling J, et al.
J Clin Med
. 2024 Oct;
13(20).
PMID: 39458030
The KDM1A histone demethylase regulates the cellular balance between proliferation and differentiation, and is often deregulated in human cancers including the childhood tumor neuroblastoma. We previously showed that KDM1A is...
12.
Laugwitz L, Mechtler T, Janzen N, Oliva P, Kasper A, Teunissen C, et al.
N Engl J Med
. 2024 Sep;
391(13):1256-1258.
PMID: 39292923
No abstract available.
13.
Stober M, Chamorro Gonzalez R, Bruckner L, Conrad T, Wittstruck N, Szymansky A, et al.
Cell Rep
. 2024 Sep;
43(9):114711.
PMID: 39255063
Neuroblastoma exhibits significant inter- and intra-tumor genetic heterogeneity and varying clinical outcomes. Extrachromosomal DNAs (ecDNAs) may drive this heterogeneity by independently segregating during cell division, leading to rapid oncogene amplification....
14.
Ector C, Schmal C, Didier J, De Landtsheer S, Finger A, Muller-Marquardt F, et al.
Nat Commun
. 2024 Aug;
15(1):7205.
PMID: 39169017
The circadian clock, a fundamental biological regulator, governs essential cellular processes in health and disease. Circadian-based therapeutic strategies are increasingly gaining recognition as promising avenues. Aligning drug administration with the...
15.
Flaadt T, Jaki C, Maier C, Amorelli G, Klingebiel T, Schlegel P, et al.
Cytotherapy
. 2024 Jun;
26(10):1227-1235.
PMID: 38904583
Background And Aims: High-dose chemotherapy (HDC) followed by autologous stem cell transplantation (ASCT) improves the prognosis in pediatric patients with several solid tumors and lymphomas. Little is known about the...
16.
Trautwein N, Schwenck J, Seitz C, Seith F, Calderon E, von Beschwitz S, et al.
Theranostics
. 2024 Feb;
14(3):1212-1223.
PMID: 38323317
The tumor-associated disialoganglioside GD2 is a immunotherapy target in neuroblastoma and other childhood tumors, including Ewing sarcoma and osteosarcoma. GD2-targeting antibodies proved to be effective in neuroblastoma and GD2-targeting chimeric...
17.
Li X, Wirtz T, Weber T, Lebedin M, Lowenstein E, Sommermann T, et al.
Sci Immunol
. 2024 Feb;
9(92):eadi0042.
PMID: 38306418
Familial hemophagocytic lymphohistiocytosis (FHL) is an inherited, often fatal immune deficiency characterized by severe systemic hyperinflammation. Although allogeneic bone marrow transplantation can be curative, more effective therapies are urgently needed....
18.
Groll A, Schulte J, Antmen A, Fraser C, Teal V, Haber B, et al.
Pediatr Infect Dis J
. 2024 Jan;
43(3):203-208.
PMID: 38241643
Introduction: Letermovir is a cytomegalovirus (CMV) terminase complex inhibitor approved for prophylaxis of CMV infection and disease in adult CMV-seropositive allogeneic hematopoietic cell transplantation (allo-HCT) recipients (R+). We report pharmacokinetics...
19.
Bei Y, Brame L, Kirchner M, Fritsche-Guenther R, Kunz S, Bhattacharya A, et al.
Cancer Discov
. 2024 Jan;
14(3):492-507.
PMID: 38197697
Significance: We demonstrate that coamplification of passenger genes, which were largely neglected in cancer biology in the past, can create distinct cancer dependencies. Because passenger coamplifications are frequent in cancer,...
20.
Pusch F, Dorado Garcia H, Xu R, Gurgen D, Bei Y, Bruckner L, et al.
Mol Cancer Ther
. 2023 Dec;
23(4):507-519.
PMID: 38159110
The small-molecule inhibitor of ataxia telangiectasia and Rad3-related protein (ATR), elimusertib, is currently being tested clinically in various cancer entities in adults and children. Its preclinical antitumor activity in pediatric...