Johanne Pastor
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Explore the profile of Johanne Pastor including associated specialties, affiliations and a list of published articles.
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19
Citations
642
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Recent Articles
1.
Controlled dietary phosphate loading in healthy young men elevates plasma phosphate and FGF23 levels
Gerber J, Pastor Arroyo E, Pastor J, Correia M, Rudloff S, Moe O, et al.
Pflugers Arch
. 2024 Nov;
477(3):495-508.
PMID: 39601886
Increased dietary inorganic phosphate (P) intake stimulates renal P excretion, in part, by parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23) or dopamine. High dietary P may also stimulate sympathetic...
2.
Giacona J, Afridi A, Bezan Petric U, Johnson T, Pastor J, Ren J, et al.
J Appl Physiol (1985)
. 2024 Mar;
136(4):1007-1014.
PMID: 38482570
Highly bioavailable inorganic phosphate (Pi) is present in large quantities in the typical Western diet and represents a large fraction of total phosphate intake. Dietary Pi excess induces exercise intolerance...
3.
Yoon J, Liu Z, Lee E, Liu L, Ferre S, Pastor J, et al.
J Am Soc Nephrol
. 2021 Sep;
32(12):3051-3065.
PMID: 34551996
Background: The kidney is the source of sKlotho and kidney-specific loss of Klotho leads to a phenotype resembling the premature multiorgan failure phenotype in Klotho-hypomorphic mice ( kl/kl mice). Klotho...
4.
Li L, Pastor J, Zhang J, Davidson T, Hu M, Moe O
FASEB Bioadv
. 2021 Jul;
3(7):531-540.
PMID: 34258522
Alpha-Klotho is a multi-functional protein essential for maintenance of a myriad of cell functions. αKlotho is a single transmembrane protein with a large extracellular segment consisting of two domains (termed...
5.
Neyra J, Moe O, Pastor J, Gianella F, Sidhu S, Sarnak M, et al.
Clin Kidney J
. 2020 Apr;
13(2):235-244.
PMID: 32297879
Background: Soluble Klotho has multiple systemic salutary effects. In animals, both acute and chronic kidney disease models display systemic Klotho deficiency. As such, there is considerable interest in investigating soluble...
6.
Neyra J, Li X, Mescia F, Ortiz-Soriano V, Adams-Huet B, Pastor J, et al.
Crit Care Explor
. 2020 Mar;
1(6).
PMID: 32123869
Objective: Klotho and Fibroblast Growth Factor (FGF)-23 were recently postulated as candidate biomarkers and/or therapeutic targets in acute kidney injury (AKI). We examined whether urine Klotho and serum intact FGF23...
7.
Dhayat N, Pruijm M, Ponte B, Ackermann D, Leichtle A, Devuyst O, et al.
J Clin Endocrinol Metab
. 2019 Nov;
105(4).
PMID: 31774122
Context: α-klotho is an integral membrane protein that serves as a coreceptor for fibroblast growth factor 23 (FGF23) in conjunction with cognate fibroblast growth factor receptors. Proteolytic cleavage sheds the...
8.
9.
Pastor-Arroyo E, Gehring N, Krudewig C, Costantino S, Bettoni C, Knopfel T, et al.
Kidney Int
. 2018 May;
94(1):49-59.
PMID: 29735309
High circulating fibroblast growth factor 23 (FGF23) levels are probably a major risk factor for cardiovascular disease in chronic kidney disease. FGF23 interacts with the receptor FGFR4 in cardiomyocytes inducing...
10.
Gazdhar A, Ravikumar P, Pastor J, Heller M, Ye J, Zhang J, et al.
Stem Cells
. 2017 Dec;
36(4):616-625.
PMID: 29226550
Induced pluripotent stem cells (iPSCs) have been reported to alleviate organ injury, although the mechanisms of action remain unclear and administration of intact cells faces many limitations. We hypothesized that...