Johan Paulsson
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Explore the profile of Johan Paulsson including associated specialties, affiliations and a list of published articles.
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58
Citations
3935
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Recent Articles
11.
Luro S, Potvin-Trottier L, Okumus B, Paulsson J
Nat Methods
. 2019 Nov;
17(1):93-100.
PMID: 31768062
Single-cell genetic screens can be incredibly powerful, but current high-throughput platforms do not track dynamic processes, and even for non-dynamic properties they struggle to separate mutants of interest from phenotypic...
12.
Riglar D, Richmond D, Potvin-Trottier L, Verdegaal A, Naydich A, Bakshi S, et al.
Nat Commun
. 2019 Oct;
10(1):4665.
PMID: 31604953
Synthetic gene oscillators have the potential to control timed functions and periodic gene expression in engineered cells. Such oscillators have been refined in bacteria in vitro, however, these systems have...
13.
Lord N, Norman T, Yuan R, Bakshi S, Losick R, Paulsson J
Science
. 2019 Oct;
366(6461):116-120.
PMID: 31604312
Cell fate decision circuits must be variable enough for genetically identical cells to adopt a multitude of fates, yet ensure that these states are distinct, stably maintained, and coordinated with...
14.
Yan J, Hilfinger A, Vinnicombe G, Paulsson J
Phys Rev Lett
. 2019 Oct;
123(10):108101.
PMID: 31573304
Nonequilibrium stochastic reaction networks are commonly found in both biological and nonbiological systems, but have remained hard to analyze because small differences in rate functions or topology can change the...
15.
16.
Lepore A, Taylor H, Landgraf D, Okumus B, Jaramillo-Riveri S, McLaren L, et al.
Sci Rep
. 2019 May;
9(1):7902.
PMID: 31133640
Cell biology is increasingly dependent on quantitative methods resulting in the need for microscopic labelling technologies that are highly sensitive and specific. Whilst the use of fluorescent proteins has led...
17.
Potvin-Trottier L, Luro S, Paulsson J
Curr Opin Microbiol
. 2018 Mar;
43:186-192.
PMID: 29494845
Bacteria have molecules present in low and fluctuating numbers that randomize cell behaviors. Understanding these stochastic processes and their impact on cells has, until recently, been limited by the lack...
18.
Single-cell microscopy of suspension cultures using a microfluidics-assisted cell screening platform
Okumus B, Baker C, Arias-Castro J, Lai G, Leoncini E, Bakshi S, et al.
Nat Protoc
. 2017 Dec;
13(1):170-194.
PMID: 29266097
Studies that rely on fluorescence imaging of nonadherent cells that are cultured in suspension, such as Escherichia coli, are often hampered by trade-offs that must be made between data throughput...
19.
Russell J, Cabeen M, Wiggins P, Paulsson J, Losick R
EMBO J
. 2017 Aug;
36(19):2856-2869.
PMID: 28838935
Entry into sporulation in is governed by a phosphorelay in which phosphoryl groups from a histidine kinase are successively transferred via relay proteins to the response regulator Spo0A. Spo0A~P, in...
20.
Cabeen M, Russell J, Paulsson J, Losick R
PLoS Genet
. 2017 Jul;
13(7):e1006901.
PMID: 28727759
Bacteria use a variety of stress-sensing systems to sense and respond to diverse stressors and to ensure their survival under adverse conditions. The gram-positive bacterium Bacillus subtilis responds to energy...