Andreas Hilfinger
Overview
Explore the profile of Andreas Hilfinger including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
313
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Recent Articles
1.
Fan R, Hilfinger A
Phys Rev E
. 2024 Oct;
110(3-1):034309.
PMID: 39425385
Cells sense environmental signals and transmit information intracellularly through changes in the abundance of molecular components. Such molecular abundances can be measured in single cells and exhibit significant heterogeneity in...
2.
Jager K, Orozco-Hidalgo M, Springstein B, Joly-Smith E, Papazotos F, McDonough E, et al.
Proc Natl Acad Sci U S A
. 2023 Sep;
120(39):e2221539120.
PMID: 37738299
Prions are self-propagating protein aggregates formed by specific proteins that can adopt alternative folds. Prions were discovered as the cause of the fatal transmissible spongiform encephalopathies in mammals, but prions...
3.
Kell B, Ripsman R, Hilfinger A
Proc Natl Acad Sci U S A
. 2023 Sep;
120(38):e2302016120.
PMID: 37695915
A key goal of synthetic biology is to develop functional biochemical modules with network-independent properties. Antithetic integral feedback (AIF) is a recently developed control module in which two control species...
4.
Diep P, Kell B, Yakunin A, Hilfinger A, Mahadevan R
Anal Biochem
. 2023 Jun;
676:115182.
PMID: 37355028
Many proteins bind transition metal ions as cofactors to carry out their biological functions. Despite binding affinities for divalent transition metal ions being predominantly dictated by the Irving-Williams series for...
5.
Jager K, Orozco-Hidalgo M, Springstein B, Joly-Smith E, Papazotos F, McDonough E, et al.
bioRxiv
. 2023 Jan;
PMID: 36712035
Prions are self-propagating protein aggregates formed by specific proteins that can adopt alternative folds. Prions were discovered as the cause of the fatal transmissible spongiform encephalopathies in mammals, but prions...
6.
Fan R, Hilfinger A
Biophys J
. 2023 Jan;
122(5):905-923.
PMID: 36698314
Small regulatory RNA molecules such as microRNA modulate gene expression through inhibiting the translation of messenger RNA (mRNA). Such posttranscriptional regulation has been recently hypothesized to reduce the stochastic variability...
7.
Wittenstein T, Leibovich N, Hilfinger A
PLoS Comput Biol
. 2022 Jun;
18(6):e1010183.
PMID: 35731728
Quantifying biochemical reaction rates within complex cellular processes remains a key challenge of systems biology even as high-throughput single-cell data have become available to characterize snapshots of population variability. That...
8.
Kaufman T, Nitzan E, Firestein N, Ginzberg M, Iyengar S, Patel N, et al.
Nat Commun
. 2022 May;
13(1):2725.
PMID: 35585055
While multiplexing samples using DNA barcoding revolutionized the pace of biomedical discovery, multiplexing of live imaging-based applications has been limited by the number of fluorescent proteins that can be deconvoluted...
9.
Joly-Smith E, Wang Z, Hilfinger A
Phys Rev E
. 2021 Nov;
104(4-1):044406.
PMID: 34781497
Inferring functional relationships within complex networks from static snapshots of a subset of variables is a ubiquitous problem in science. For example, a key challenge of systems biology is to...
10.
Tan C, Ginzberg M, Webster R, Iyengar S, Liu S, Papadopoli D, et al.
Dev Cell
. 2021 May;
56(12):1756-1769.e7.
PMID: 34022133
While molecules that promote the growth of animal cells have been identified, it remains unclear how such signals are orchestrated to determine a characteristic target size for different cell types....