Nathan D Lord
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Explore the profile of Nathan D Lord including associated specialties, affiliations and a list of published articles.
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11
Citations
463
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Recent Articles
1.
Emig A, Hansen M, Grimm S, Coarfa C, Lord N, Williams M
Development
. 2024 Dec;
PMID: 39651654
Anteroposterior (AP) elongation of the vertebrate body plan is driven by convergence and extension (C&E) gastrulation movements in both the mesoderm and neuroectoderm, but how or whether molecular regulation of...
2.
McNamara H, Jia B, Guyer A, Parot V, Dobbs C, Schier A, et al.
bioRxiv
. 2024 Apr;
PMID: 38645239
A crucial step in early embryogenesis is the establishment of spatial patterns of signaling activity. Tools to perturb morphogen signals with high resolution in space and time can help reveal...
3.
Emig A, Hansen M, Grimm S, Coarfa C, Lord N, Williams M
bioRxiv
. 2024 Feb;
PMID: 38370754
Anteroposterior (AP) elongation of the vertebrate body plan is driven by convergence and extension (C&E) gastrulation movements in both the mesoderm and neuroectoderm, but how or whether molecular regulation of...
4.
Lord N, Carte A, Abitua P, Schier A
Elife
. 2021 May;
10.
PMID: 34036935
Embryos must communicate instructions to their constituent cells over long distances. These instructions are often encoded in the concentration of signals called morphogens. In the textbook view, morphogen molecules diffuse...
5.
Lord N, Norman T, Yuan R, Bakshi S, Losick R, Paulsson J
Science
. 2019 Oct;
366(6461):116-120.
PMID: 31604312
Cell fate decision circuits must be variable enough for genetically identical cells to adopt a multitude of fates, yet ensure that these states are distinct, stably maintained, and coordinated with...
6.
Rogers K, Lord N, Gagnon J, Pauli A, Zimmerman S, Aksel D, et al.
Elife
. 2017 Dec;
6.
PMID: 29215332
Developmental signaling pathways often activate their own inhibitors. Such inhibitory feedback has been suggested to restrict the spatial and temporal extent of signaling or mitigate signaling fluctuations, but these models...
7.
Norris M, Pauli A, Gagnon J, Lord N, Rogers K, Mosimann C, et al.
Elife
. 2017 Nov;
6.
PMID: 29117894
Toddler/Apela/Elabela is a conserved secreted peptide that regulates mesendoderm development during zebrafish gastrulation. Two non-exclusive models have been proposed to explain Toddler function. The 'specification model' postulates that Toddler signaling...
8.
Potvin-Trottier L, Lord N, Vinnicombe G, Paulsson J
Nature
. 2016 Oct;
538(7626):514-517.
PMID: 27732583
Synthetically engineered genetic circuits can perform a wide variety of tasks but are generally less accurate than natural systems. Here we revisit the first synthetic genetic oscillator, the repressilator, and...
9.
Uphoff S, Lord N, Okumus B, Potvin-Trottier L, Sherratt D, Paulsson J
Science
. 2016 Mar;
351(6277):1094-7.
PMID: 26941321
Cells rely on the precise action of proteins that detect and repair DNA damage. However, gene expression noise causes fluctuations in protein abundances that may compromise repair. For the Ada...
10.
Norman T, Lord N, Paulsson J, Losick R
Annu Rev Microbiol
. 2015 Sep;
69:381-403.
PMID: 26332088
Microbes transiently differentiate into distinct, specialized cell types to generate functional diversity and cope with changing environmental conditions. Though alternate programs often entail radically different physiological and morphological states, recent...