Joelle Wiels
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Explore the profile of Joelle Wiels including associated specialties, affiliations and a list of published articles.
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34
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3435
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Recent Articles
1.
Lacroix A, Farhat R, Robert A, Brenner C, Wiels J, Germini D
Front Pharmacol
. 2024 Aug;
15:1444973.
PMID: 39170706
Ovarian adenocarcinoma is the gynecological malignancy with the worst prognosis and the highest mortality rate. In the first stages of treatment, chemotherapy results effective, but its prolonged use and high...
2.
Sall F, Shmakova A, Karpukhina A, Tsfasman T, Lomov N, Canoy R, et al.
J Med Virol
. 2023 Mar;
95(3):e28633.
PMID: 36866703
Burkitt lymphoma (BL) is a B cell malignancy associated with the Epstein-Barr virus (EBV). Most BL cases are characterized by a t(8;14) chromosomal translocation involving the MYC oncogene and the...
3.
Seguy L, Daressy F, Lahlil S, Corvaisier S, Dumontet V, Litaudon M, et al.
Int J Pharm
. 2022 Nov;
630:122433.
PMID: 36436745
MCL-1, an anti-apoptotic member of the BCL-2 protein family, is overexpressed in many types of cancer and contributes to chemotherapy resistance. The drimane derivative NA1-115-7 is a natural compound isolated...
4.
Daressy F, Seguy L, Favre L, Corvaisier S, Apel C, Groo A, et al.
Biomed Pharmacother
. 2022 Aug;
154:113546.
PMID: 35988426
The overexpression of antiapoptotic members (BCL-2, BCL-xL, MCL-1, etc.) of the BCL-2 family contributes to tumor development and resistance to chemotherapy or radiotherapy. Synthetic inhibitors targeting these proteins have been...
5.
Robert A, Wiels J
Toxins (Basel)
. 2021 Oct;
13(10).
PMID: 34678982
Shiga toxins (Stxs), also known as Shiga-like toxins (SLT) or verotoxins (VT), constitute a family of structurally and functionally related cytotoxic proteins produced by the enteric pathogens type 1 and...
6.
Daressy F, Malard F, Seguy L, Guerineau V, Apel C, Dumontet V, et al.
ChemMedChem
. 2021 Mar;
16(11):1788-1797.
PMID: 33665938
Drimane sesquiterpenoid dialdehydes are natural compounds with antiproliferative properties. Nevertheless, their mode of action has not yet been discovered. Herein, we demonstrate that various drimanes are potent inhibitors of MCL-1...
7.
Canoy R, Andre F, Shmakova A, Wiels J, Lipinski M, Vassetzky Y, et al.
Gene Ther
. 2020 Oct;
30(1-2):167-171.
PMID: 32999452
B-cell lines and primary PBMCs are notoriously hard to transfect, thus making genome editing, ectopic gene expression, or gene silencing experiments particularly tedious. Here we propose a novel efficient and...
8.
Robert A, Pujals A, Favre L, Debernardi J, Wiels J
Mol Oncol
. 2020 Jul;
14(10):2520-2532.
PMID: 32623836
Post-transplant lymphoproliferative disorders (PTLD) and Burkitt's lymphoma (BL) are B-cell malignancies strongly associated with Epstein-Barr virus (EBV) infection. In these lymphoproliferative disorders, EBV infection induces an increase in the expression...
9.
Germini D, Sall F, Shmakova A, Wiels J, Dokudovskaya S, Drouet E, et al.
Cancers (Basel)
. 2020 Jun;
12(6).
PMID: 32517128
Epstein Barr Virus (EBV) is one of the most common human herpesviruses. After primary infection, it can persist in the host throughout their lifetime in a latent form, from which...
10.
Debernardi J, Pioche-Durieu C, Le Cam E, Wiels J, Robert A
Toxins (Basel)
. 2020 May;
12(5).
PMID: 32403276
Shiga toxins (Stxs) expressed by the enterohaemorrhagic and enteric pathogens are protein synthesis inhibitors. Stxs have been shown to induce apoptosis via the activation of extrinsic and intrinsic pathways in...