Fanny Roussi
Overview
Explore the profile of Fanny Roussi including associated specialties, affiliations and a list of published articles.
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Articles
63
Citations
873
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Recent Articles
1.
Weinhaupl K, Meuret L, Desrat S, Roussi F, Morellet N, Beaupierre S, et al.
Sci Rep
. 2025 Mar;
15(1):8227.
PMID: 40065114
No abstract available.
2.
Jezequel G, Fargier J, Bigay J, Polidori J, Geslin J, Hue N, et al.
ChemMedChem
. 2025 Feb;
:e202400978.
PMID: 39936924
The development of innovative antiviral strategies is critical to address the global health threats posed by RNA viruses, including the Zika virus (ZIKV), which can cause severe neurological complications. The...
3.
Schelle B, Fargier J, Grisel C, Askenatzis L, Gallard J, Desrat S, et al.
Org Biomol Chem
. 2025 Feb;
23(10):2380-2385.
PMID: 39916448
Herein, we present the first synthesis of hybrid molecules combining the pharmacophores of two natural compounds, schweinfurthin E (SW-E) and the glycosidic moiety of OSW-1. These hybrids were designed leveraging...
4.
Weinhaupl K, Meuret L, Desrat S, Roussy F, Roussi F, Morellet N, et al.
Sci Rep
. 2025 Feb;
15(1):4146.
PMID: 39900984
MtbClpC1 is a promising drug target against tuberculosis. Recent studies have shown that several natural product antibiotics targeting the unfoldase N-terminal domain can impair MtbClpC1 function resulting in cell death....
5.
Jezequel G, Grimanelli Z, Guimard C, Bigay J, Haddad J, Bignon J, et al.
J Med Chem
. 2024 Dec;
68(1):196-211.
PMID: 39704626
OSBP ligands from the ORPphilin family are chemically complex natural products with promising anticancer properties. Here, we describe macarangin B, a natural racemic flavonoid selective for OSBP, which stands out...
6.
Nothias-Esposito M, Roussi F, Paolini J, Litaudon M, Desrat S
J Nat Prod
. 2024 May;
87(6):1574-1581.
PMID: 38789921
Natural products represent a rich source of bioactive compounds, covering a large chemical space. Even if challenging, this diversity can be extended by applying chemical modifications. However, these studies generally...
7.
Jezequel G, Rampal C, Guimard C, Kovacs D, Polidori J, Bigay J, et al.
J Med Chem
. 2023 Oct;
66(20):14208-14220.
PMID: 37795600
Schweinfurthins (SWs) are naturally occurring prenylated stilbenes with promising anticancer properties. They act through a novel mechanism of action similar to that of other families of natural compounds. Their known...
8.
Apel C, Levasseur M, Lejeune C, Korch S, Guerard F, David M, et al.
Front Cell Dev Biol
. 2023 Mar;
11:1129009.
PMID: 36968208
ATP wasting is recognized as an efficient strategy to enhance metabolic activity and productivity of specific metabolites in several microorganisms However, such strategy has been rarely implemented in species whereas...
9.
Subra M, Dezi M, Bigay J, Lacas-Gervais S, Di Cicco A, Dias Araujo A, et al.
Dev Cell
. 2023 Jan;
58(2):121-138.e9.
PMID: 36693319
Membrane contact sites (MCSs) are heterogeneous in shape, composition, and dynamics. Despite this diversity, VAP proteins act as receptors for multiple FFAT motif-containing proteins and drive the formation of most...
10.
Seguy L, Daressy F, Lahlil S, Corvaisier S, Dumontet V, Litaudon M, et al.
Int J Pharm
. 2022 Nov;
630:122433.
PMID: 36436745
MCL-1, an anti-apoptotic member of the BCL-2 protein family, is overexpressed in many types of cancer and contributes to chemotherapy resistance. The drimane derivative NA1-115-7 is a natural compound isolated...