Joel R Meyerson
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Explore the profile of Joel R Meyerson including associated specialties, affiliations and a list of published articles.
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18
Citations
655
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Recent Articles
1.
He C, Mansilla-Soto J, Khanra N, Hamieh M, Bustos V, Paquette A, et al.
Sci Immunol
. 2023 Mar;
8(81):eadf1426.
PMID: 36867678
Chimeric antigen receptor (CAR) T cell therapy relies on T cells that are guided by synthetic receptors to target and lyse cancer cells. CARs bind to cell surface antigens through...
2.
Frindt G, Meyerson J, Satty A, Scandura J, Palmer L
J Gen Physiol
. 2022 Aug;
154(10).
PMID: 35939271
The epithelial Na+ channel (ENaC) is a heterotrimeric protein whose assembly, trafficking, and function are highly regulated. To better understand the biogenesis and activation of the channel, we quantified the...
3.
Selvakumar P, Fernandez-Marino A, Khanra N, He C, Paquette A, Wang B, et al.
Nat Commun
. 2022 Jul;
13(1):3854.
PMID: 35788586
The Kv1.3 potassium channel is expressed abundantly on activated T cells and mediates the cellular immune response. This role has made the channel a target for therapeutic immunomodulation to block...
4.
Therapeutic antibody activation of the glucocorticoid-induced TNF receptor by a clustering mechanism
He C, Maniyar R, Avraham Y, Zappasodi R, Rusinova R, Newman W, et al.
Sci Adv
. 2022 Feb;
8(8):eabm4552.
PMID: 35213218
GITR is a TNF receptor, and its activation promotes immune responses and drives antitumor activity. The receptor is activated by the GITR ligand (GITRL), which is believed to cluster receptors...
5.
Alegre K, Paknejad N, Su M, Lou J, Huang J, Jordan K, et al.
Nat Struct Mol Biol
. 2021 Nov;
28(11):936-944.
PMID: 34759376
The β-adrenergic receptor (β-AR) can activate two families of G proteins. When coupled to Gs, β-AR increases cardiac output, and coupling to Gi leads to decreased responsiveness in myocardial infarction....
6.
Selvakumar P, Lee J, Khanra N, He C, Munguba H, Kiese L, et al.
Cell Rep
. 2021 Oct;
37(4):109891.
PMID: 34706237
The kainate receptors (KARs) are members of the ionotropic glutamate receptor family and assemble into tetramers from a pool of five subunit types (GluK1-5). Each subunit confers distinct functional properties...
7.
Graphene Oxide-Supported Microwell Grids for Preparing Cryo-EM Samples with Controlled Ice Thickness
Kang M, Park J, Kang S, Jeon S, Lee M, Shim J, et al.
Adv Mater
. 2021 Sep;
33(43):e2102991.
PMID: 34510585
Cryogenic-electron microscopy (cryo-EM) is the preferred method to determine 3D structures of proteins and to study diverse material systems that intrinsically have radiation or air sensitivity. Current cryo-EM sample preparation...
8.
Khanra N, Brown P, Perozzo A, Bowie D, Meyerson J
Elife
. 2021 Mar;
10.
PMID: 33724189
Kainate receptors (KARs) are L-glutamate-gated ion channels that regulate synaptic transmission and modulate neuronal circuits. KARs have strict assembly rules and primarily function as heteromeric receptors in the brain. A...
9.
Su M, Zhu L, Zhang Y, Paknejad N, Dey R, Huang J, et al.
Mol Cell
. 2020 Aug;
80(1):59-71.e4.
PMID: 32818430
Cardiac disease remains the leading cause of morbidity and mortality worldwide. The β-adrenergic receptor (β-AR) is a major regulator of cardiac functions and is downregulated in the majority of heart...
10.
Meyerson J, Chittori S, Merk A, Rao P, Han T, Serpe M, et al.
Nature
. 2016 Sep;
537(7621):567-571.
PMID: 27580033
Glutamate receptors are ligand-gated tetrameric ion channels that mediate synaptic transmission in the central nervous system. They are instrumental in vertebrate cognition and their dysfunction underlies diverse diseases. In both...