Joel P Charles
Overview
Explore the profile of Joel P Charles including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
230
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0
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Recent Articles
1.
Vogiatzi F, Brandt D, Schneikert J, Fuchs J, Grikscheit K, Wanzel M, et al.
Proc Natl Acad Sci U S A
. 2016 Dec;
113(52):E8433-E8442.
PMID: 27956623
Mutations in the p53 tumor suppressor gene are the most frequent genetic alteration in cancer and are often associated with progression from benign to invasive stages with metastatic potential. Mutations...
2.
Bretz A, Gittler M, Charles J, Gremke N, Eckhardt I, Mernberger M, et al.
Nucleic Acids Res
. 2016 Jan;
44(7):3204-18.
PMID: 26819410
TP63, a member of the p53 gene family gene, encodes the ΔNp63 protein and is one of the most frequently amplified genes in squamous cell carcinomas (SCC) of the head...
3.
Wanzel M, Vischedyk J, Gittler M, Gremke N, Seiz J, Hefter M, et al.
Nat Chem Biol
. 2015 Nov;
12(1):22-8.
PMID: 26595461
Inactivation of the p53 tumor suppressor by Mdm2 is one of the most frequent events in cancer, so compounds targeting the p53-Mdm2 interaction are promising for cancer therapy. Mechanisms conferring...
4.
Charles J, Fuchs J, Hefter M, Vischedyk J, Kleint M, Vogiatzi F, et al.
Nat Commun
. 2014 Jun;
5:3981.
PMID: 24889111
Tumours are heterogeneous cell populations that undergo clonal evolution during tumour progression, metastasis and response to therapy. Short hairpin RNAs (shRNAs) generate stable loss-of-function phenotypes and are versatile experimental tools...
5.
Schlereth K, Charles J, Bretz A, Stiewe T
Cell Cycle
. 2010 Oct;
9(20):4068-76.
PMID: 20948308
The tumor suppressor p53 provides exquisite protection from cancer by balancing cell survival and death in response to stress. Sustained stress or irreparable damage trigger p53's killer functions to permanently...
6.
Schlereth K, Beinoraviciute-Kellner R, Zeitlinger M, Bretz A, Sauer M, Charles J, et al.
Mol Cell
. 2010 May;
38(3):356-68.
PMID: 20471942
p53 limits the proliferation of precancerous cells by inducing cell-cycle arrest or apoptosis. How the decision between survival and death is made at the level of p53 binding to target...