Michael Wanzel
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Explore the profile of Michael Wanzel including associated specialties, affiliations and a list of published articles.
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23
Citations
1012
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Recent Articles
1.
Funk J, Klimovich M, Drangenstein D, Pielhoop O, Hunold P, Borowek A, et al.
Nat Genet
. 2025 Jan;
57(1):140-153.
PMID: 39774325
The mutational landscape of TP53, a tumor suppressor mutated in about half of all cancers, includes over 2,000 known missense mutations. To fully leverage TP53 mutation status for personalized medicine,...
2.
Pavlakis E, Neumann M, Merle N, Wieboldt R, Wanzel M, Ponath V, et al.
J Exp Clin Cancer Res
. 2023 Aug;
42(1):203.
PMID: 37563605
Background: TP53, encoding the tumor suppressor p53, is frequently mutated in various cancers, producing mutant p53 proteins (mutp53) which can exhibit neomorphic, gain-of-function properties. The latter transform p53 into an...
3.
Sailer S, Lechner S, Flossmann A, Wanzel M, Habeler K, Krasny C, et al.
J Orthop Traumatol
. 2023 Feb;
24(1):6.
PMID: 36765020
Background: Allograft bone screws are rarely described for the fixation of the scaphoid. When fresh fractures are treated, metal screws are mainly used; when pseudarthrosis is the indication, plates in...
4.
Merle N, Elmshauser S, Strassheimer F, Wanzel M, Konig A, Funk J, et al.
Mol Cancer
. 2022 Oct;
21(1):191.
PMID: 36192757
Background: In vivo gene editing of somatic cells with CRISPR nucleases has facilitated the generation of autochthonous mouse tumors, which are initiated by genetic alterations relevant to the human disease...
5.
Mandic R, Marquardt A, Terhorst P, Ali U, Nowak-Rossmann A, Cai C, et al.
BMC Cancer
. 2022 Jul;
22(1):785.
PMID: 35850701
Background: More than twenty years after its discovery, the role of the importin beta superfamily member Ran GTP-binding protein (RanBP) 17 is still ill defined. Previously, we observed notable RanBP17...
6.
Polo P, Gremke N, Stiewe T, Wanzel M
Cells
. 2022 Jun;
11(11).
PMID: 35681458
Autophagy allows cells to temporarily tolerate energy stress by replenishing critical metabolites through self-digestion, thereby attenuating the cytotoxic effects of anticancer drugs that target tumor metabolism. Autophagy defects could therefore...
7.
Das Gupta D, Paul C, Samel N, Bieringer M, Staudenraus D, Marini F, et al.
Cell Death Differ
. 2022 Apr;
29(11):2163-2176.
PMID: 35459909
The processes leading from disturbed B-cell development to adult B-cell progenitor acute lymphoblastic leukemia (BCP-ALL) remain poorly understood. Here, we describe Irf4 mice as prone to developing BCP-ALL with age....
8.
Matrood S, de Prisco N, Wissniowski T, Wiese D, Jabari S, Griesmann H, et al.
Neuroendocrinology
. 2020 Oct;
111(10):965-985.
PMID: 33108790
Introduction: Autophagic cell death in cancer cells can be mediated by inhibition of deacetylases. Although extensive studies have focused on the autophagic process in cancer, little is known about the...
9.
Gremke N, Polo P, Dort A, Schneikert J, Elmshauser S, Brehm C, et al.
Nat Commun
. 2020 Sep;
11(1):4684.
PMID: 32943635
Cancer cells have a characteristic metabolism, mostly caused by alterations in signal transduction networks rather than mutations in metabolic enzymes. For metabolic drugs to be cancer-selective, signaling alterations need to...
10.
Moftakhar T, Wanzel M, Vojcsik A, Kralinger F, Mousavi M, Hajdu S, et al.
Arch Orthop Trauma Surg
. 2020 Aug;
141(7):1207-1213.
PMID: 32852595
Purpose: Electric scooters (e-scooters) are an emerging way of mobility in cities around the world. Despite quickly rising numbers of e-scooters, limited studies report on incidence and severity of e-scooter-associated...