Joel Jules
Overview
Explore the profile of Joel Jules including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
463
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Recent Articles
1.
Chen S, Shi Z, Jules J, Li Y, Kesterson R, Elbahoty M, et al.
Bone
. 2024 Dec;
192:117367.
PMID: 39667419
RANKL and its receptor RANK play a vital role in osteoclastogenesis. RANK primarily recruits TRAFs to promote osteoclastogenesis but also contains an TRAF-independent motif (IVVY), which mediates osteoclast lineage commitment...
2.
Wu M, Li C, Zhu G, Wang Y, Jules J, Lu Y, et al.
Bone
. 2019 Jun;
125:207-208.
PMID: 31208734
No abstract available.
3.
Li Y, Shi Z, Jules J, Chen S, Kesterson R, Zhao D, et al.
J Bone Miner Res
. 2019 Jun;
34(10):1938-1951.
PMID: 31173390
Upon receptor activator of NF-κB ligand (RANKL) binding, RANK promotes osteoclast formation through the recruitment of tumor necrosis factor (TNF) receptor-associated factors (TRAFs). In vitro assays identified two RANK intracellular...
4.
Chen W, Zhu G, Jules J, Nguyen D, Li Y
J Bone Miner Res
. 2017 Nov;
33(4):691-703.
PMID: 29149533
CCAAT/enhancer-binding protein α (C/ebpα) is critical for osteoclastogenesis by regulating osteoclast (OC) lineage commitment and is also important for OC differentiation and function in vitro. However, the role of C/ebpα...
5.
Jules J, Chen W, Feng X, Li Y
J Biol Chem
. 2017 Nov;
293(4):1480-1492.
PMID: 29122885
Binding of receptor activator of NF-κB ligand (RANKL) to its receptor RANK on osteoclast (OC) precursors up-regulates c-Fos and CCAAT/enhancer-binding protein-α (C/EBPα), two critical OC transcription factors. However, the effects...
6.
Jules J, Li Y, Chen W
Bone
. 2017 Oct;
107:104-114.
PMID: 29032174
The transcription factors C/EBPα and PU.1 are upregulated by RANKL through activation of its receptor RANK during osteoclastogenesis and are critical for osteoclast differentiation. Herein we investigated the mechanisms underlying...
7.
Jules J, Chen W, Feng X, Li Y
J Biol Chem
. 2016 Apr;
291(31):16390-403.
PMID: 27129246
CCAAT/enhancer-binding protein (C/EBPα) can appoint mouse bone marrow (MBM) cells to the osteoclast (OC) lineage for osteoclastogenesis. However, whether C/EBPα is also involved in OC differentiation and activity is unknown....
8.
Braley A, Kwak T, Jules J, Harja E, Landgraf R, Hudson B
J Biol Chem
. 2016 Mar;
291(23):12057-73.
PMID: 27022018
The receptor for advanced glycation end products (RAGE) is a multiligand transmembrane receptor that can undergo proteolysis at the cell surface to release a soluble ectodomain. Here we observed that...
9.
Jules J, Wang S, Shi Z, Liu J, Wei S, Feng X
J Biol Chem
. 2015 Aug;
290(39):23738-50.
PMID: 26276390
Receptor activator of NF-κB (RANK) activation by RANK ligand (RANKL) mediates osteoclastogenesis by recruiting TNF receptor-associated factors (TRAFs) via three cytoplasmic motifs (motif 1, PFQEP(369-373); motif 2, PVQEET(559-564); and motif...
10.
Jules J, Yang S, Chen W, Li Y
Prog Mol Biol Transl Sci
. 2015 Jul;
133:47-75.
PMID: 26123302
Regulators of G protein signaling (RGS) proteins enhance the intrinsic GTPase activity of α subunits of the heterotrimeric G protein complex of G protein-coupled receptors (GPCRs) and thereby inactivate signal...