Joel Hrit
Overview
Explore the profile of Joel Hrit including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
245
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0
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Recent Articles
1.
Qian C, Lee Y, Han Y, Zhong Y, Zhou J, Hrit J, et al.
J Med Chem
. 2025 Feb;
68(3):2903-2919.
PMID: 39905966
DNA methyltransferase 1 (DNMT1), which catalyzes maintenance methylation of hemimethylated DNA during DNA replication, is overexpressed in cancer. Recently, the first-in-class DNMT1-selective noncovalent small-molecule inhibitors, GSK3484862 and GSK3685032, were discovered....
2.
Ferrand J, Dabin J, Chevallier O, Kane-Charvin M, Kupai A, Hrit J, et al.
Nat Commun
. 2025 Jan;
16(1):746.
PMID: 39820273
The faithful segregation of intact genetic material and the perpetuation of chromatin states through mitotic cell divisions are pivotal for maintaining cell function and identity across cell generations. However, most...
3.
Tiedemann R, Hrit J, Du Q, Wiseman A, Eden H, Dickson B, et al.
Nucleic Acids Res
. 2024 Nov;
52(22):13733-13756.
PMID: 39607687
The RING E3 ubiquitin ligase UHRF1 is an established cofactor for DNA methylation inheritance. The model posits that nucleosomal engagement through histone and DNA interactions directs UHRF1 ubiquitin ligase activity...
4.
Francois A, Rohani A, Loftus M, Dochnal S, Hrit J, McFarlane S, et al.
mBio
. 2024 Feb;
15(4):e0327823.
PMID: 38411116
Importance: Investigating the potential mechanisms of gene silencing for DNA viruses in different cell types is important to understand the differential outcomes of infection, particularly for viruses like herpesviruses that...
5.
Tiedemann R, Hrit J, Du Q, Wiseman A, Eden H, Dickson B, et al.
bioRxiv
. 2024 Feb;
PMID: 38405904
The RING E3 ubiquitin ligase UHRF1 is an established cofactor for DNA methylation inheritance. Nucleosomal engagement through histone and DNA interactions directs UHRF1 ubiquitin ligase activity toward lysines on histone...
6.
Francois A, Rohani A, Loftus M, Dochnal S, Hrit J, McFarlane S, et al.
bioRxiv
. 2023 Dec;
PMID: 38076966
The fate of herpesvirus genomes following entry into different cell types is thought to regulate the outcome of infection. For the Herpes simplex virus 1 (HSV-1), latent infection of neurons...
7.
Ferrand J, Dabin J, Chevallier O, Kane-Charvin M, Kupai A, Hrit J, et al.
bioRxiv
. 2023 Sep;
PMID: 37732208
The faithful segregation of intact genetic material and the perpetuation of chromatin states through mitotic cell divisions are pivotal for maintaining cell function and identity across cell generations. However, most...
8.
Reske J, Wilson M, Armistead B, Harkins S, Perez C, Hrit J, et al.
BMC Biol
. 2022 Sep;
20(1):209.
PMID: 36153585
Background: SWI/SNF (BAF) chromatin remodeling complexes regulate lineage-specific enhancer activity by promoting accessibility for diverse DNA-binding factors and chromatin regulators. Additionally, they are known to modulate the function of the...
9.
Armache A, Yang S, Martinez de Paz A, Robbins L, Durmaz C, Cheong J, et al.
Nature
. 2020 Jul;
583(7818):852-857.
PMID: 32699416
Complex organisms can rapidly induce select genes in response to diverse environmental cues. This regulation occurs in the context of large genomes condensed by histone proteins into chromatin. The sensing...
10.
Colino-Sanguino Y, Cornett E, Moulder D, Smith G, Hrit J, Cordeiro-Spinetti E, et al.
iScience
. 2019 Nov;
21:773-788.
PMID: 31727574
Acetylation of the histone variant H2A.Z (H2A.Zac) occurs at active regulatory regions associated with gene expression. Although the Tip60 complex is proposed to acetylate H2A.Z, functional studies suggest additional enzymes...