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» Authors » Joe Jongpyo Lim

Joe Jongpyo Lim

Explore the profile of Joe Jongpyo Lim including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 45
Followers 0
Related Specialties
Toxicology
Pharmacology
Top 10 Co-Authors
Julia Yue Cui
Hans-Joachim Lehmler
Haiwei Gu
Moumita Dutta
Xueshu Li
Yan Jin
Michael Goedken
Joseph L Dempsey
Sridhar Mani
Deepak K Bhatt
Published In
Toxicol Sci
Drug Metab Dispos
Environ Toxicol Pharmacol
Affiliations
Soon will be listed here.
Recent Articles
1.
Deciphering the cell type-specific and zonal distribution of drug-metabolizing enzymes, transporters, and transcription factors in livers of mice using single-cell transcriptomics
Lim J, Klaassen C, Cui J
Drug Metab Dispos . 2025 Feb; 53(2):100029. PMID: 39919554
The liver contains multiple cell types, including resident cell types and immune cells. The liver is also categorized into 3 zones: periportal (zone 1), midzonal (zone 2), and centrilobular (zone...
2.
Single-cell transcriptomics unveiled that early life BDE-99 exposure reprogrammed the gut-liver axis to promote a proinflammatory metabolic signature in male mice at late adulthood
Lim J, Goedken M, Jin Y, Gu H, Cui J
Toxicol Sci . 2024 Apr; 200(1):114-136. PMID: 38648751
Polybrominated diphenyl ethers (PBDEs) are legacy flame retardants that bioaccumulate in the environment. The gut microbiome is an important regulator of liver functions including xenobiotic biotransformation and immune regulation. We...
3.
The disposition of polychlorinated biphenyls (PCBs) differs between germ-free and conventional mice
Li X, Lim J, Wang K, Prasad B, Bhatt D, Cui J, et al.
Environ Toxicol Pharmacol . 2022 Mar; 92:103854. PMID: 35331926
The disposition of toxicants, such as polychlorinated biphenyls (PCBs), in germ-free (GF) vs. conventional (CV) mice has received little attention to date. Here, we investigate PCB levels in three-month-old female...
4.
Pregnane X Receptor and the Gut-Liver Axis: A Recent Update
Dutta M, Lim J, Cui J
Drug Metab Dispos . 2021 Dec; 50(4):478-491. PMID: 34862253
It is well-known that the pregnane X receptor (PXR)/Nr1i2 is a critical xenobiotic-sensing nuclear receptor enriched in liver and intestine and is responsible for drug-drug interactions, due to its versatile...
5.
Perfluorinated Carboxylic Acids with Increasing Carbon Chain Lengths Upregulate Amino Acid Transporters and Modulate Compensatory Response of Xenobiotic Transporters in HepaRG Cells
Lim J, Suh Y, Faustman E, Cui J
Drug Metab Dispos . 2021 Dec; 50(10):1396-1413. PMID: 34857530
Perfluorinated carboxylic acids (PFCAs) are widespread environmental pollutants for which human exposure has been documented. PFCAs at high doses are known to regulate xenobiotic transporters partly through peroxisome proliferator-activated receptor...
6.
Neonatal Exposure to BPA, BDE-99, and PCB Produces Persistent Changes in Hepatic Transcriptome Associated With Gut Dysbiosis in Adult Mouse Livers
Lim J, Dutta M, Dempsey J, Lehmler H, MacDonald J, Bammler T, et al.
Toxicol Sci . 2021 Aug; 184(1):83-103. PMID: 34453844
Recent evidence suggests that complex diseases can result from early life exposure to environmental toxicants. Polybrominated diphenyl ethers (PBDEs), and polychlorinated biphenyls (PCBs) are persistent organic pollutants (POPs) and remain...
7.
Gut Microbiome Critically Impacts PCB-induced Changes in Metabolic Fingerprints and the Hepatic Transcriptome in Mice
Lim J, Li X, Lehmler H, Wang D, Gu H, Cui J
Toxicol Sci . 2020 Jun; 177(1):168-187. PMID: 32544245
Polychlorinated biphenyls (PCBs) are ubiquitously detected and have been linked to metabolic diseases. Gut microbiome is recognized as a critical regulator of disease susceptibility; however, little is known how PCBs...