Jochen Kuhse
Overview
Explore the profile of Jochen Kuhse including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
20
Citations
252
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Kiss E, Kins S, Gorgas K, Venczel Szakacs K, Kirsch J, Kuhse J
Int J Mol Sci
. 2024 Apr;
25(8).
PMID: 38673751
Plant-derived multitarget compounds may represent a promising therapeutic strategy for multifactorial diseases, such as Alzheimer's disease (AD). Artemisinin and its derivatives were indicated to beneficially modulate various aspects of AD...
2.
Kuhse J, Groeneweg F, Kins S, Gorgas K, Nawrotzki R, Kirsch J, et al.
Int J Mol Sci
. 2023 Mar;
24(5).
PMID: 36902054
Alzheimer's disease (AD) is characterized by synaptic failure and neuronal loss. Recently, we demonstrated that artemisinins restored the levels of key proteins of inhibitory GABAergic synapses in the hippocampus of...
3.
Kiss E, Kins S, Zoller Y, Schilling S, Gorgas K, Gross D, et al.
Mol Cell Neurosci
. 2021 May;
113:103624.
PMID: 33933588
Alzheimer's disease (AD) is the most frequent form of dementia, characterized histopathologically by the formation of amyloid plaques and neurofibrillary tangles in the brain. Amyloid β-peptide (Aβ) is a major...
4.
Kiss E, Kins S, Gorgas K, Orlik M, Fischer C, Endres K, et al.
Biol Chem
. 2021 Apr;
403(1):73-87.
PMID: 33878252
Artemisinins, a group of plant-derived sesquiterpene lactones, are efficient antimalarial agents. They also share anti-inflammatory and anti-viral activities and were considered for treatment of neurodegenerative disorders like Alzheimer's disease (AD)....
5.
Zhou L, Kiss E, Demmig R, Kirsch J, Nawrotzki R, Kuhse J
Histochem Cell Biol
. 2021 Apr;
156(1):5-18.
PMID: 33796945
Gephyrin is a multifunctional scaffolding protein anchoring glycine- and subtypes of GABA type A- receptors at inhibitory postsynaptic membrane specializations by binding to the microtubule (MT) and/or the actin cytoskeleton....
6.
Kiss E, Groeneweg F, Gorgas K, Schlicksupp A, Kins S, Kirsch J, et al.
J Alzheimers Dis
. 2020 Mar;
74(4):1167-1187.
PMID: 32144981
Early changes in inhibitory synapse connectivities are thought to contribute to the excitation/inhibition imbalance preceding neurodegeneration in Alzheimer's disease (AD). Recently, we reported a robust increase in the level of...
7.
Hollnagel J, Elzoheiry S, Gorgas K, Kins S, Beretta C, Kirsch J, et al.
PLoS One
. 2019 Jan;
14(1):e0209228.
PMID: 30645585
Several lines of evidence imply changes in inhibitory interneuron connectivity and subsequent alterations in oscillatory network activities in the pathogenesis of Alzheimer's Disease (AD). Recently, we provided evidence for an...
8.
Groeneweg F, Trattnig C, Kuhse J, Nawrotzki R, Kirsch J
Histochem Cell Biol
. 2018 Sep;
150(5):489-508.
PMID: 30264265
Scaffolding proteins underlying postsynaptic membrane specializations are important structural and functional components of both excitatory and inhibitory synapses. At inhibitory synapses, gephyrin was identified as anchoring protein. Gephyrin self-assembles into...
9.
Kiss E, Gorgas K, Schlicksupp A, Gross D, Kins S, Kirsch J, et al.
Am J Pathol
. 2016 Jul;
186(9):2279-91.
PMID: 27423698
The pathogenesis of Alzheimer disease (AD) is thought to begin many years before the diagnosis of dementia. Accumulating evidence indicates the involvement of GABAergic neurotransmission in the physiopathology of AD....
10.
OSullivan G, Jedlicka P, Chen H, Kalbouneh H, Ippolito A, Deller T, et al.
Mol Cell Neurosci
. 2016 Feb;
72:101-13.
PMID: 26829712
Mutations that result in the defective trafficking of γ2 subunit containing GABAA receptors (γ2-GABAARs) are known to reduce synaptic inhibition. Whether perturbed clustering of non-mutated GABAARs similarly reduces synaptic inhibition...