Joanna W Jachowicz
Overview
Explore the profile of Joanna W Jachowicz including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
596
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Recent Articles
1.
de Luca K, Rullens P, Karpinska M, de Vries S, Gacek-Matthews A, Pongor L, et al.
Nat Commun
. 2024 Nov;
15(1):9918.
PMID: 39572529
Accurate repair of DNA damage is critical for maintenance of genomic integrity and cellular viability. Because damage occurs non-uniformly across the genome, single-cell resolution is required for proper interrogation, but...
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Goronzy I, Quinodoz S, Jachowicz J, Ollikainen N, Bhat P, Guttman M
Cell Rep
. 2022 Nov;
41(9):111730.
PMID: 36450242
Mammalian genomes are organized into three-dimensional DNA structures called A/B compartments that are associated with transcriptional activity/inactivity. However, whether these structures are simply correlated with gene expression or are permissive/impermissible...
4.
Jachowicz J
Methods Mol Biol
. 2022 Nov;
2607:355-368.
PMID: 36449170
This protocol describes methods to design, assemble, and validate tools for targeted activation or repression of single-copy and multi-copy genes, including repetitive and transposable elements. It uses transcription activator-like effector...
5.
Jachowicz J, Strehle M, Banerjee A, Blanco M, Thai J, Guttman M
Nat Struct Mol Biol
. 2022 Mar;
29(3):239-249.
PMID: 35301492
Although thousands of long non-coding RNAs (lncRNAs) are encoded in mammalian genomes, their mechanisms of action are poorly understood, in part because they are often expressed at lower levels than...
6.
Quinodoz S, Bhat P, Chovanec P, Jachowicz J, Ollikainen N, Detmar E, et al.
Nat Protoc
. 2022 Jan;
17(1):36-75.
PMID: 35013617
A fundamental question in gene regulation is how cell-type-specific gene expression is influenced by the packaging of DNA within the nucleus of each cell. We recently developed Split-Pool Recognition of...
7.
Markaki Y, Gan Chong J, Wang Y, Jacobson E, Luong C, Tan S, et al.
Cell
. 2021 Dec;
184(25):6212.
PMID: 34890555
No abstract available.
8.
Markaki Y, Gan Chong J, Wang Y, Jacobson E, Luong C, Tan S, et al.
Cell
. 2021 Nov;
184(25):6174-6192.e32.
PMID: 34813726
The lncRNA Xist forms ∼50 diffraction-limited foci to transcriptionally silence one X chromosome. How this small number of RNA foci and interacting proteins regulate a much larger number of X-linked...
9.
Quinodoz S, Jachowicz J, Bhat P, Ollikainen N, Banerjee A, Goronzy I, et al.
Cell
. 2021 Nov;
184(23):5775-5790.e30.
PMID: 34739832
RNA, DNA, and protein molecules are highly organized within three-dimensional (3D) structures in the nucleus. Although RNA has been proposed to play a role in nuclear organization, exploring this has...
10.
Arrastia M, Jachowicz J, Ollikainen N, Curtis M, Lai C, Quinodoz S, et al.
Nat Biotechnol
. 2021 Aug;
40(1):64-73.
PMID: 34426703
Although three-dimensional (3D) genome organization is central to many aspects of nuclear function, it has been difficult to measure at the single-cell level. To address this, we developed 'single-cell split-pool...