Joanna Trylska
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Explore the profile of Joanna Trylska including associated specialties, affiliations and a list of published articles.
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98
Citations
1130
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Recent Articles
1.
DellAcqua R, Fagnani F, Wojciechowska M, Marinotto D, Colombo G, Dalle-Donne I, et al.
Dalton Trans
. 2025 Jan;
54(8):3314-3322.
PMID: 39831467
The synthesis of novel highly phosphorescent N^C^N tridentate platinum(II)-complex-peptide nucleic acid (PNA) bioconjugates was accomplished through the solid-phase approach. Melting temperature measurements and circular dichroism spectroscopy studies demonstrated that these...
2.
Siekierska I, Burmistrz M, Trylska J
Bioorg Med Chem Lett
. 2024 Oct;
114:129993.
PMID: 39426432
Antisense oligonucleotides have been developed as therapeutic compounds, with peptide nucleic acid (PNA) emerging as a promising nucleic acid mimic for antimicrobial applications. To be effective, PNAs must be internalized...
3.
Chyzy P, Kulik M, Shinobu A, Re S, Sugita Y, Trylska J
Proc Natl Acad Sci U S A
. 2024 Apr;
121(15):e2317197121.
PMID: 38579011
Riboswitches are messenger RNA (mRNA) fragments binding specific small molecules to regulate gene expression. A synthetic N1 riboswitch, inserted into yeast mRNA controls the translation of a reporter gene in...
4.
Tsylents U, Burmistrz M, Wojciechowska M, Stepien J, Maj P, Trylska J
Front Microbiol
. 2024 Feb;
15:1331021.
PMID: 38357356
Bacteria secrete various iron-chelators (siderophores), which scavenge Fe from the environment, bind it with high affinity, and retrieve it inside the cell. After the Fe uptake, bacteria extract the soluble...
5.
Macyszyn J, Chyzy P, Burmistrz M, Lobka M, Miszkiewicz J, Wojciechowska M, et al.
Sci Rep
. 2023 Sep;
13(1):14826.
PMID: 37684254
Given the widespread demand for novel antibacterial agents, we modified a cell-penetrating peptide (KFF)K to transform it into an antibacterial peptide. Namely, we inserted a hydrocarbon staple into the (KFF)K...
6.
Tsylents U, Siekierska I, Trylska J
Eur Biophys J
. 2023 Aug;
52(6-7):533-544.
PMID: 37610696
Peptide nucleic acid (PNA) is a nucleic acid mimic with high specificity and binding affinity to natural DNA or RNA, as well as resistance to enzymatic degradation. PNA sequences can...
7.
Conjugates of Aminoglycosides with Stapled Peptides as a Way to Target Antibiotic-Resistant Bacteria
Macyszyn J, Burmistrz M, Mieczkowski A, Wojciechowska M, Trylska J
ACS Omega
. 2023 Jun;
8(21):19047-19056.
PMID: 37273645
The misuse and overuse of antibiotics led to the development of bacterial resistance to existing aminoglycoside (AMG) antibiotics and limited their use. Consequently, there is a growing need to develop...
8.
Ostrowska N, Feig M, Trylska J
PLoS Comput Biol
. 2023 Apr;
19(4):e1011054.
PMID: 37098073
Biochemical processes in cells, including enzyme-catalyzed reactions, occur in crowded conditions with various background macromolecules occupying up to 40% of cytoplasm's volume. Viral enzymes in the host cell also encounter...
9.
Dyzma A, Wielgus-Kutrowska B, Girstun A, Jelic Matosevic Z, Staron K, Bertosa B, et al.
Int J Mol Sci
. 2023 Feb;
24(3).
PMID: 36768477
Mammalian purine nucleoside phosphorylase (PNP) is biologically active as a homotrimer, in which each monomer catalyzes a reaction independently of the others. To answer the question of why the native...
10.
Wojciechowska M, Macyszyn J, Miszkiewicz J, Grzela R, Trylska J
Front Microbiol
. 2021 Dec;
12:772038.
PMID: 34966367
Anoplin is a linear 10-amino acid amphipathic peptide (Gly-Leu-Leu-Lys-Arg-Ile-Lys-Thr-Leu-Leu- ) derived from the venom sac of the solitary wasp. It has broad antimicrobial activity, including an antibacterial one. However, the...