Joan Serratosa
Overview
Explore the profile of Joan Serratosa including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
956
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0
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Recent Articles
1.
Llaves-Lopez A, Micoli E, Belmonte-Mateos C, Aguilar G, Alba C, Marsal A, et al.
Mol Neurobiol
. 2024 Jun;
62(1):756-772.
PMID: 38900366
Microglia, the main resident immune cells in the central nervous system, are implicated in the pathogenesis of various neurological disorders. Much of our knowledge on microglial biology was obtained using...
2.
Rabaneda-Lombarte N, Serratosa J, Bove J, Vila M, Saura J, Sola C
J Neuroinflammation
. 2021 Apr;
18(1):88.
PMID: 33823877
Background: It is suggested that neuroinflammation, in which activated microglial cells play a relevant role, contributes to the development of Parkinson's disease (PD). Consequently, the modulation of microglial activation is...
3.
Rabaneda-Lombarte N, Blasco-Agell L, Serratosa J, Ferigle L, Saura J, Sola C
Sci Rep
. 2020 Jul;
10(1):10650.
PMID: 32606391
Exposure to pesticides such as rotenone is a risk factor for Parkinson's disease. Dopaminergic neurons are especially sensitive to the toxicity of compounds that inhibit the mitochondrial respiratory chain such...
4.
Rabaneda-Lombarte N, Xicoy-Espaulella E, Serratosa J, Saura J, Sola C
Front Mol Neurosci
. 2019 Jan;
11:479.
PMID: 30686998
In the case of Parkinson's disease (PD), epidemiological studies have reported that pesticide exposure is a risk factor for its pathology. It has been suggested that some chemical agents, such...
5.
Bachs O, Gallastegui E, Orlando S, Bigas A, Morante-Redolat J, Serratosa J, et al.
Oncotarget
. 2018 Jun;
9(40):26259-26278.
PMID: 29899857
The protein p27 is a member of the Cip/Kip family of cyclin-dependent kinase (Cdk) inhibitors. It interacts with both the catalytic and the regulatory subunit (cyclin) and introduces a region...
6.
Gallastegui E, Domuro C, Serratosa J, Larrieux A, Sin L, Martinez J, et al.
Oncotarget
. 2018 Apr;
9(23):16368-16379.
PMID: 29662651
Alpha-synuclein (α-SYN) is the main component of anomalous protein aggregates (Lewy bodies) that play a crucial role in several neurodegenerative diseases (synucleinopathies) like Parkinson's disease and multiple system atrophy. However,...
7.
Valente T, Serratosa J, Perpina U, Saura J, Sola C
Front Cell Neurosci
. 2017 May;
11:129.
PMID: 28522962
In the brain of patients with multiple sclerosis, activated microglia/macrophages appear in active lesions and in normal appearing white matter. However, whether they play a beneficial or a detrimental role...
8.
Pulido-Salgado M, Vidal-Taboada J, Garcia Diaz-Barriga G, Serratosa J, Valente T, Castillo P, et al.
J Neuroinflammation
. 2017 Mar;
14(1):54.
PMID: 28302135
Background: CCAAT/enhancer binding protein β (C/EBPβ) is a transcription factor that regulates the expression of important pro-inflammatory genes in microglia. Mice deficient for C/EBPβ show protection against excitotoxic and ischemic...
9.
Macias-Vidal J, Giros M, Guerrero M, Gascon P, Serratosa J, Bachs O, et al.
FEBS J
. 2014 Aug;
281(19):4450-66.
PMID: 25131710
Niemann-Pick disease type C (NPC) is a lipid storage disorder mainly caused by mutations in the NPC1 gene. Approximately 60% of these mutations are missense changes that may induce reduced...
10.
Dentesano G, Serratosa J, Tusell J, Ramon P, Valente T, Saura J, et al.
Glia
. 2014 Mar;
62(6):982-98.
PMID: 24639050
The mechanisms that control microglial activation are of interest, since neuroinflammation, which involves reactive microglia, may be an additional target in the search for therapeutic strategies to treat neurodegenerative diseases....