Joachim Mittendorf
Overview
Explore the profile of Joachim Mittendorf including associated specialties, affiliations and a list of published articles.
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20
Citations
436
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Recent Articles
1.
Furstner C, Ackerstaff J, Meier H, Straub A, Mittendorf J, Schamberger J, et al.
J Med Chem
. 2024 Nov;
PMID: 39541507
Chymase is a serine-protease produced by mast cells. In the past few decades, its role in fibrotic diseases triggered the search for orally available chymase inhibitors. Aiming at reducing adverse...
2.
Vakalopoulos A, Basting D, Brechmann M, Teller H, Boultadakis Arapinis M, Straub A, et al.
J Med Chem
. 2024 Oct;
67(21):19165-19187.
PMID: 39463278
Autonomic disbalance, i.e., sympathetic overactivation and parasympathetic withdrawal, is a causal driver of disease progression in heart failure. While sympatholytic drugs are established treatments, no drug therapy restoring vagal control...
3.
Meibom D, Wasnaire P, Beyer K, Broehl A, Cancho-Grande Y, Elowe N, et al.
J Med Chem
. 2024 Feb;
67(4):2907-2940.
PMID: 38348661
The matrix metalloprotease ADAMTS7 has been identified by multiple genome-wide association studies as being involved in the development of coronary artery disease. Subsequent research revealed the proteolytic function of the...
4.
Vakalopoulos A, Wunder F, Hartung I, Redlich G, Jautelat R, Buchgraber P, et al.
J Med Chem
. 2023 Apr;
66(11):7280-7303.
PMID: 37040336
Herein, we describe the identification, chemical optimization, and preclinical characterization of novel soluble guanylate cyclase (sGC) stimulators. Given the very broad therapeutic opportunities for sGC stimulators, new tailored molecules for...
5.
Meibom D, Meyer J, von Buehler C, Collins K, Maassen S, Gericke K, et al.
J Med Chem
. 2023 Mar;
66(7):4659-4670.
PMID: 36932954
After acute myocardial infarction, early reperfusion is the most effective strategy for reducing cardiac damage and improving clinical outcome. However, restoring blood flow to the ischemic myocardium can paradoxically induce...
6.
Hahn M, Lampe T, El Sheikh S, Griebenow N, Woltering E, Schlemmer K, et al.
J Med Chem
. 2021 Apr;
64(9):5323-5344.
PMID: 33872507
Herein we describe the discovery, mode of action, and preclinical characterization of the soluble guanylate cyclase (sGC) activator runcaciguat. The sGC enzyme, via the formation of cyclic guanosine monophoshphate, is...
7.
Le Roux A, Blaise E, Boudreault P, Comeau C, Doucet A, Giarrusso M, et al.
J Med Chem
. 2020 May;
63(13):6774-6783.
PMID: 32453569
We herein report the first thorough analysis of the structure-permeability relationship of semipeptidic macrocycles. In total, 47 macrocycles were synthesized using a hybrid solid-phase/solution strategy, and then their passive and...
8.
Follmann M, Ackerstaff J, Redlich G, Wunder F, Lang D, Kern A, et al.
J Med Chem
. 2017 May;
60(12):5146-5161.
PMID: 28557445
The first-in-class soluble guanylate cyclase (sGC) stimulator riociguat was recently introduced as a novel treatment option for pulmonary hypertension. Despite its outstanding pharmacological profile, application of riociguat in other cardiovascular...
9.
Meibom D, Albrecht-Kupper B, Diedrichs N, Hubsch W, Kast R, Kramer T, et al.
ChemMedChem
. 2017 May;
12(10):728-737.
PMID: 28488817
Adenosine is known to be released under a variety of physiological and pathophysiological conditions to facilitate the protection and regeneration of injured ischemic tissues. The activation of myocardial adenosine A...
10.
von Nussbaum F, Li V, Meibom D, Anlauf S, Bechem M, Delbeck M, et al.
ChemMedChem
. 2015 Sep;
11(2):199-206.
PMID: 26333652
Human neutrophil elastase (HNE) is a key driver of inflammation in many cardiopulmonary and systemic inflammatory and autoimmune conditions. Overshooting high HNE activity is the consequence of a disrupted protease-antiprotease...