Alpha 2.0
Login Register
» Authors » Martina Schafer

Martina Schafer

Explore the profile of Martina Schafer including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 35
Citations 412
Followers 0
Related Specialties
Chemistry
Pharmacology
Biochemistry
Top 10 Co-Authors
Ulrich Lucking
Hans Briem
Philip Lienau
Gerhard Siemeister
Franz von Nussbaum
Joachim Mittendorf
Karsten Denner
Judith Gunther
Ulf Bomer
Reinhard Nubbemeyer
Published In
J Med Chem
ChemMedChem
Angew Chem Int Ed Engl
Chemistry
Inorg Chem
Affiliations
Soon will be listed here.
Recent Articles
1.
Discovery and Preclinical Characterization of Fulacimstat (BAY 1142524), a Potent and Selective Chymase Inhibitor As a New Profibrinolytic Approach for Safe Thrombus Resolution
Furstner C, Ackerstaff J, Meier H, Straub A, Mittendorf J, Schamberger J, et al.
J Med Chem . 2024 Nov; PMID: 39541507
Chymase is a serine-protease produced by mast cells. In the past few decades, its role in fibrotic diseases triggered the search for orally available chymase inhibitors. Aiming at reducing adverse...
2.
Discovery of BAY 2413555, First Selective Positive Allosteric Modulator of the M2 Receptor to Restore Cardiac Autonomic Balance
Vakalopoulos A, Basting D, Brechmann M, Teller H, Boultadakis Arapinis M, Straub A, et al.
J Med Chem . 2024 Oct; 67(21):19165-19187. PMID: 39463278
Autonomic disbalance, i.e., sympathetic overactivation and parasympathetic withdrawal, is a causal driver of disease progression in heart failure. While sympatholytic drugs are established treatments, no drug therapy restoring vagal control...
3.
Discovery of BAY-405: An Azaindole-Based MAP4K1 Inhibitor for the Enhancement of T-Cell Immunity against Cancer
Mowat J, Carretero R, Leder G, Aiguabella Font N, Neuhaus R, Berndt S, et al.
J Med Chem . 2024 Sep; 67(19):17429-17453. PMID: 39331123
Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1) is a serine/threonine kinase that acts as an immune checkpoint downstream of T-cell receptor stimulation. MAP4K1 activity is enhanced by prostaglandin E2...
4.
Fostering reflective impact orientation in transdisciplinary research-A multi-method workshop format
Schafer M, Nagy E, Kny J
MethodsX . 2024 Jul; 13:102795. PMID: 39007029
The primary objective of transdisciplinary research (TDR) is to contribute to the solution of complex 'real-world' problems by integrating heterogeneous knowledge and achieving societal effects. However, establishing a continuous impact...
5.
Healthy, Inclusive and Sustainable Catering in Secondary Schools-An Analysis of a Transformation Process with Multiple Tensions
Hennchen B, Schafer M
Int J Environ Res Public Health . 2024 Mar; 21(3). PMID: 38541369
Interest in catering for public sector schools is increasing due to its potential role in addressing the prevailing problems of malnutrition, food insecurity and non-sustainable food habits. Based on the...
6.
Discovery of IRAK4 Inhibitors (Zabedosertib) and
Bothe U, Gunther J, Nubbemeyer R, Siebeneicher H, Ring S, Bomer U, et al.
J Med Chem . 2024 Jan; 67(2):1225-1242. PMID: 38228402
Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a critical role in innate inflammatory processes. Here, we describe the discovery of two clinical candidate IRAK4 inhibitors, (zabedosertib) and , starting from a...
7.
Changing for the Better: Discovery of the Highly Potent and Selective CDK9 Inhibitor VIP152 Suitable for Once Weekly Intravenous Dosing for the Treatment of Cancer
Lucking U, Kosemund D, Bohnke N, Lienau P, Siemeister G, Denner K, et al.
J Med Chem . 2021 Jul; 64(15):11651-11674. PMID: 34264057
Selective inhibition of exclusively transcription-regulating positive transcription elongation factor b/CDK9 is a promising new approach in cancer therapy. Starting from atuveciclib, the first selective CDK9 inhibitor to enter clinical development,...
8.
Food practices as part of daily routines: A conceptual framework for analysing networks of practices
Castelo A, Schafer M, Silva M
Appetite . 2020 Sep; 157:104978. PMID: 32980458
Current debates about the need to change daily practices to address sustainability or health issues often neglect to recognise that single practices like eating are embedded in daily routines and...
9.
Discovery and Characterization of BAY 1214784, an Orally Available Spiroindoline Derivative Acting as a Potent and Selective Antagonist of the Human Gonadotropin-Releasing Hormone Receptor as Proven in a First-In-Human Study in Postmenopausal Women
Panknin O, Wagenfeld A, Bone W, Bender E, Nowak-Reppel K, Fernandez-Montalvan A, et al.
J Med Chem . 2020 Sep; 63(20):11854-11881. PMID: 32960053
The growth of uterine fibroids is sex hormone-dependent and commonly associated with highly incapacitating symptoms. Most treatment options consist of the control of these hormonal effects, ultimately blocking proliferative estrogen...
10.
Damage Incorporated: Discovery of the Potent, Highly Selective, Orally Available ATR Inhibitor BAY 1895344 with Favorable Pharmacokinetic Properties and Promising Efficacy in Monotherapy and in Combination Treatments in Preclinical Tumor Models
Lucking U, Wortmann L, Wengner A, Lefranc J, Lienau P, Briem H, et al.
J Med Chem . 2020 Jun; 63(13):7293-7325. PMID: 32502336
The ATR kinase plays a key role in the DNA damage response by activating essential signaling pathways of DNA damage repair, especially in response to replication stress. Because DNA damage...