Joachim A F Oude Vrielink
Overview
Explore the profile of Joachim A F Oude Vrielink including associated specialties, affiliations and a list of published articles.
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10
Citations
1809
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Recent Articles
1.
Slobodin B, Han R, Calderone V, Vrielink J, Loayza-Puch F, Elkon R, et al.
Cell
. 2017 Apr;
169(2):326-337.e12.
PMID: 28388414
Transcription and translation are two main pillars of gene expression. Due to the different timings, spots of action, and mechanisms of regulation, these processes are mainly regarded as distinct and...
2.
Melo C, Drost J, Wijchers P, van de Werken H, de Wit E, Vrielink J, et al.
Mol Cell
. 2013 Jan;
49(3):524-35.
PMID: 23273978
Binding within or nearby target genes involved in cell proliferation and survival enables the p53 tumor suppressor gene to regulate their transcription and cell-cycle progression. Using genome-wide chromatin-binding profiles, we...
3.
Elkon R, Drost J, van Haaften G, Jenal M, Schrier M, Vrielink J, et al.
Genome Biol
. 2012 Jul;
13(7):R59.
PMID: 22747694
Background: The majority of mammalian genes contain multiple poly(A) sites in their 3' UTRs. Alternative cleavage and polyadenylation are emerging as an important layer of gene regulation as they generate...
4.
Jenal M, Elkon R, Loayza-Puch F, van Haaften G, Kuhn U, Menzies F, et al.
Cell
. 2012 Apr;
149(3):538-53.
PMID: 22502866
Alternative cleavage and polyadenylation (APA) is emerging as an important layer of gene regulation. Factors controlling APA are largely unknown. We developed a reporter-based RNAi screen for APA and identified...
5.
Gomez-Benito M, Loayza-Puch F, Vrielink J, Oude Vrielink J, Odero M, Agami R
PLoS One
. 2011 Oct;
6(10):e25449.
PMID: 21998658
Translocations involving the Mixed Lineage Leukemia (MLL) gene generate in-frame fusions of MLL with more than 50 different partner genes (PGs). Common to all MLL translocations is the exchange not...
6.
Lerner M, Lundgren J, Akhoondi S, Jahn A, Ng H, Akbari Moqadam F, et al.
Cell Cycle
. 2011 May;
10(13):2172-83.
PMID: 21597324
The F-box protein FBW7/hCDC4 is a tumor suppressor that acts as the substrate recognition component of an SCF ubiquitin ligase that targets numerous oncoproteins for proteasomal degradation. In this study,...
7.
Kedde M, Van Kouwenhove M, Zwart W, Vrielink J, Elkon R, Agami R
Nat Cell Biol
. 2010 Sep;
12(10):1014-20.
PMID: 20818387
Key regulators of 3' untranslated regions (3' UTRs) are microRNAs and RNA-binding proteins (RBPs). The p27 tumour suppressor is highly expressed in quiescent cells, and its downregulation is required for...
8.
Ferras C, Vrielink J, Verspuy J, Te Riele H, Tsaalbi-Shtylik A, de Wind N
Mol Ther
. 2009 May;
17(8):1373-80.
PMID: 19471249
A substantial fraction of sporadic and inherited colorectal and endometrial cancers in humans is deficient in DNA mismatch repair (MMR). These cancers are characterized by length alterations in ubiquitous simple...
9.
Nagel R, le Sage C, Diosdado B, van der Waal M, Vrielink J, Bolijn A, et al.
Cancer Res
. 2008 Jul;
68(14):5795-802.
PMID: 18632633
Inactivation of the adenomatous polyposis coli (APC) gene is a major initiating event in colorectal tumorigenesis. Most of the mutations in APC generate premature stop codons leading to truncated proteins...
10.
Kedde M, Strasser M, Boldajipour B, Vrielink J, Slanchev K, le Sage C, et al.
Cell
. 2007 Dec;
131(7):1273-86.
PMID: 18155131
MicroRNAs (miRNAs) are inhibitors of gene expression capable of controlling processes in normal development and cancer. In mammals, miRNAs use a seed sequence of 6-8 nucleotides (nt) to associate with...