Jingjin Ding
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Explore the profile of Jingjin Ding including associated specialties, affiliations and a list of published articles.
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40
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5722
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Recent Articles
1.
Ren K, Farrell J, Li Y, Guo X, Xie R, Liu X, et al.
Nat Commun
. 2025 Jan;
16(1):1011.
PMID: 39856083
Regulator of cell death-1 (RCD-1) governs the heteroallelic expression of RCD-1-1 and RCD-1-2, a pair of fungal gasdermin (GSDM)-like proteins, which prevent cytoplasmic mixing during allorecognition and safeguard against mycoparasitism,...
2.
Dissecting caspase-2-mediated cell death: from intrinsic PIDDosome activation to chemical modulation
Zeng M, Wang K, Wu Q, Ding J, Xie D, Qi X, et al.
Protein Cell
. 2024 Apr;
15(12):889-905.
PMID: 38676703
Caspase-2, a highly conserved member of the caspase family, is considered an initiator caspase that triggers apoptosis in response to some cellular stresses. Previous studies suggest that an intracellular multi-protein...
3.
Li Y, Hou Y, Sun Q, Zeng H, Meng F, Tian X, et al.
Science
. 2024 Apr;
384(6697):adm9190.
PMID: 38662913
Gasdermins (GSDMs) are pore-forming proteins that execute pyroptosis for immune defense. GSDMs are two-domain proteins activated by proteolytic removal of the inhibitory domain. In this work, we report two types...
4.
Shi X, Sun Q, Hou Y, Zeng H, Cao Y, Dong M, et al.
Nature
. 2023 Nov;
624(7991):442-450.
PMID: 37993714
The canonical (caspase-1) and noncanonical (comprising caspases 4, 5 and 11; hereafter, caspase-4/5/11) inflammasomes both cleave gasdermin D (GSDMD) to induce pyroptosis. Whereas caspase-1 processes IL-1β and IL-18 for maturation,...
5.
Sun Y, Wang X, Yang X, Wang L, Ding J, Wang C, et al.
Dev Cell
. 2023 Nov;
58(23):2761-2775.e5.
PMID: 37922908
Endoplasmic reticulum (ER)-phagy is crucial to regulate the function and homeostasis of the ER via lysosomal degradation, but how it is initiated is unclear. Here we discover that Z-AAT, a...
6.
Wang K, Ding J, Shao F
Methods Mol Biol
. 2023 Aug;
2696:149-167.
PMID: 37578722
The gasdermin family represents a type of membrane pore-forming proteins. The gasdermin family is extensively characterized as the executioner of pyroptotic cell death in mammals; recent studies suggest that gasdermin-like...
7.
Zhong X, Zeng H, Zhou Z, Su Y, Cheng H, Hou Y, et al.
Nature
. 2023 Mar;
616(7957):598-605.
PMID: 36991125
Cytotoxic lymphocyte-derived granzyme A (GZMA) cleaves GSDMB, a gasdermin-family pore-forming protein, to trigger target cell pyroptosis. GSDMB and the charter gasdermin family member GSDMD have been inconsistently reported to be...
8.
Hou Y, Zeng H, Li Z, Feng N, Meng F, Xu Y, et al.
Nat Struct Mol Biol
. 2023 Jan;
30(3):261-272.
PMID: 36624349
The caspase-4/11-GSDMD pyroptosis axis recognizes cytosolic lipopolysaccharide for antibacterial defenses. Shigella flexneri employs an OspC3 effector to block pyroptosis by catalyzing NAD-dependent arginine ADP-riboxanation of caspase-4/11. Here, we identify Ca-free...
9.
Tian X, Liu X, Ding J, Wang F, Wang K, Liu J, et al.
Nat Biomed Eng
. 2022 Nov;
7(1):8-23.
PMID: 36424464
The cell-surface glycoprotein CD98-a subunit of the LAT1/CD98 amino acid transporter-is an attractive target for cancer immunotherapies, but its widespread expression has hampered the development of CD98-targeting antibody therapeutics. Here...
10.
Liu Y, Zeng H, Hou Y, Li Z, Li L, Song X, et al.
mBio
. 2022 Apr;
13(3):e0069022.
PMID: 35446120
Blocking host cell death is an important virulence strategy employed by many bacterial pathogens. We recently reported that Shigella flexneri inhibits host pyroptosis by delivering a type III secretion system...