Jindrich Symersky
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Explore the profile of Jindrich Symersky including associated specialties, affiliations and a list of published articles.
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26
Citations
719
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Recent Articles
1.
Luo M, Zhou W, Patel H, Srivastava A, Symersky J, Bonar M, et al.
Commun Biol
. 2020 Aug;
3(1):452.
PMID: 32814813
Bedaquiline (BDQ, Sirturo) has been approved to treat multidrug resistant forms of Mycobacterium tuberculosis. Prior studies suggested that BDQ was a selective inhibitor of the ATP synthase from M. tuberculosis....
2.
Structure and mechanism of a redesigned multidrug transporter from the Major Facilitator Superfamily
Wu H, Symersky J, Lu M
Sci Rep
. 2020 Mar;
10(1):3949.
PMID: 32127561
The rapid increase of multidrug resistance poses urgent threats to human health. Multidrug transporters prompt multidrug resistance by exporting different therapeutics across cell membranes, often by utilizing the H electrochemical...
3.
Wu H, Symersky J, Lu M
Commun Biol
. 2019 Jun;
2:210.
PMID: 31240248
MdfA is a prototypical H-coupled multidrug transporter that is characterized by extraordinarily broad substrate specificity. The involvement of specific H-bonds in MdfA-drug interactions and the simplicity of altering the substrate...
4.
Srivastava A, Luo M, Zhou W, Symersky J, Bai D, Chambers M, et al.
Science
. 2018 Apr;
360(6389).
PMID: 29650704
Mitochondrial adenosine triphosphate (ATP) synthase comprises a membrane embedded F motor that rotates to drive ATP synthesis in the F subunit. We used single-particle cryo-electron microscopy (cryo-EM) to obtain structures...
5.
Nie R, Stark S, Symersky J, Kaplan R, Lu M
Nat Commun
. 2017 Apr;
8:15009.
PMID: 28436435
Integral membrane proteins of the divalent anion/Na symporter (DASS) family translocate dicarboxylate, tricarboxylate or sulphate across cell membranes, typically by utilizing the preexisting Na gradient. The molecular determinants for substrate...
6.
Symersky J, Guo Y, Wang J, Lu M
Acta Crystallogr D Biol Crystallogr
. 2015 Nov;
71(Pt 11):2287-96.
PMID: 26527145
NorM from Neisseria gonorrhoeae (NorM-NG) belongs to the multidrug and toxic compound extrusion (MATE) family of membrane-transport proteins, which can extrude cytotoxic chemicals across cell membranes and confer multidrug resistance....
7.
Radchenko M, Symersky J, Nie R, Lu M
Nat Commun
. 2015 Aug;
6:7995.
PMID: 26246409
Multidrug and toxic compound extrusion (MATE) transporters underpin multidrug resistance by using the H(+) or Na(+) electrochemical gradient to extrude different drugs across cell membranes. MATE transporters can be further...
8.
Lu M, Radchenko M, Symersky J, Nie R, Guo Y
Nat Struct Mol Biol
. 2013 Oct;
20(11):1310-7.
PMID: 24141706
Multidrug and toxic compound extrusion (MATE) transporters contribute to multidrug resistance by coupling the efflux of drugs to the influx of Na(+) or H(+). Known structures of Na(+)-coupled, extracellular-facing MATE...
9.
Lu M, Symersky J, Radchenko M, Koide A, Guo Y, Nie R, et al.
Proc Natl Acad Sci U S A
. 2013 Jan;
110(6):2099-104.
PMID: 23341609
Multidrug transporters belonging to the multidrug and toxic compound extrusion (MATE) family expel dissimilar lipophilic and cationic drugs across cell membranes by dissipating a preexisting Na(+) or H(+) gradient. Despite...
10.
Symersky J, Osowski D, Walters D, Mueller D
Proc Natl Acad Sci U S A
. 2012 Aug;
109(35):13961-5.
PMID: 22869738
We report the high-resolution (1.9 Å) crystal structure of oligomycin bound to the subunit c(10) ring of the yeast mitochondrial ATP synthase. Oligomycin binds to the surface of the c(10)...