Jin Billy Li
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Explore the profile of Jin Billy Li including associated specialties, affiliations and a list of published articles.
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6944
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Recent Articles
11.
Hu S, Heraud-Farlow J, Sun T, Liang Z, Goradia A, Taylor S, et al.
bioRxiv
. 2023 Feb;
PMID: 36747811
Effective immunity requires the innate immune system to distinguish foreign (non-self) nucleic acids from cellular (self) nucleic acids. Cellular double-stranded RNAs (dsRNAs) are edited by the RNA editing enzyme ADAR1...
12.
Adamska J, Verma R, Gupta S, Hagan T, Wimmers F, Floyd K, et al.
Cell Rep
. 2023 Feb;
42(1):112038.
PMID: 36732946
Under normal homeostatic conditions, self-double-stranded RNA (self-dsRNA) is modified by adenosine deaminase acting on RNA 1 (ADAR1) to prevent the induction of a type I interferon-mediated inflammatory cascade. Antigen-presenting cells...
13.
Berry C, Olivares G, Gallicchio L, Ramaswami G, Glavic A, Olguin P, et al.
Genes Dev
. 2022 Sep;
36(15-16):916-935.
PMID: 36175033
Alternative polyadenylation (APA) generates transcript isoforms that differ in the position of the 3' cleavage site, resulting in the production of mRNA isoforms with different length 3' UTRs. Although widespread,...
14.
Li Q, Gloudemans M, Geisinger J, Fan B, Aguet F, Sun T, et al.
Nature
. 2022 Aug;
608(7923):569-577.
PMID: 35922514
A major challenge in human genetics is to identify the molecular mechanisms of trait-associated and disease-associated variants. To achieve this, quantitative trait locus (QTL) mapping of genetic variants with intermediate...
15.
Reautschnig P, Wahn N, Wettengel J, Schulz A, Latifi N, Vogel P, et al.
Nat Biotechnol
. 2022 Jan;
40(5):759-768.
PMID: 34980913
RNA base editing represents a promising alternative to genome editing. Recent approaches harness the endogenous RNA-editing enzyme adenosine deaminase acting on RNA (ADAR) to circumvent problems caused by ectopic expression...
16.
Li D, Liu Y, Yi P, Zhu Z, Li W, Zhang Q, et al.
Science
. 2021 Aug;
373(6558):984-991.
PMID: 34446600
Protein kinase activity must be precisely regulated, but how a cell governs hyperactive kinases remains unclear. In this study, we generated a constitutively active mitogen-activated protein kinase DYF-5 (DYF-5CA) in...
17.
Liu X, Sun T, Shcherbina A, Li Q, Jarmoskaite I, Kappel K, et al.
Nat Commun
. 2021 Apr;
12(1):2165.
PMID: 33846332
Adenosine-to-inosine (A-to-I) RNA editing catalyzed by ADAR enzymes occurs in double-stranded RNAs. Despite a compelling need towards predictive understanding of natural and engineered editing events, how the RNA sequence and...
18.
Freund E, Sapiro A, Li Q, Linder S, Moresco J, Yates 3rd J, et al.
Cell Rep
. 2020 May;
31(7):107656.
PMID: 32433965
Adenosine-to-inosine RNA editing is catalyzed by adenosine deaminase acting on RNA (ADAR) enzymes that deaminate adenosine to inosine. Although many RNA editing sites are known, few trans regulators have been...
19.
Sapiro A, Freund E, Restrepo L, Qiao H, Bhate A, Li Q, et al.
Cell Rep
. 2020 May;
31(7):107654.
PMID: 32433963
Adenosine-to-inosine RNA editing, catalyzed by adenosine deaminase acting on RNA (ADAR) enzymes, alters RNA sequences from those encoded by DNA. These editing events are dynamically regulated, but few trans regulators...
20.
Deng P, Khan A, Jacobson D, Sambrani N, McGurk L, Li X, et al.
Nat Commun
. 2020 Mar;
11(1):1580.
PMID: 32221286
ADAR RNA editing enzymes are high-affinity dsRNA-binding proteins that deaminate adenosines to inosines in pre-mRNA hairpins and also exert editing-independent effects. We generated a Drosophila Adar mutant strain encoding a...