Jin Billy Li
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Explore the profile of Jin Billy Li including associated specialties, affiliations and a list of published articles.
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77
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6944
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Recent Articles
1.
Heraud-Farlow J, Taylor S, Chalk A, Escudero A, Hu S, Goradia A, et al.
Sci Immunol
. 2024 Nov;
9(101):eadk0412.
PMID: 39576872
Adenosine-to-inosine (A-to-I) editing of double-stranded RNA (dsRNA) by ADAR1 is an essential modifier of the immunogenicity of cellular dsRNA. The role of MDA5 in sensing unedited cellular dsRNA and the...
2.
Xu L, Peng F, Luo Q, Ding Y, Yuan F, Zheng L, et al.
Cell
. 2024 Oct;
187(25):7248-7266.e34.
PMID: 39419025
Chemotherapy is often combined with immune checkpoint inhibitor (ICIs) to enhance immunotherapy responses. Despite the approval of chemo-immunotherapy in multiple human cancers, many immunologically cold tumors remain unresponsive. The mechanisms...
3.
Zak H, Rozenfeld E, Levi M, Deng P, Gorelick D, Pozeilov H, et al.
Sci Adv
. 2024 Sep;
10(36):eadi9101.
PMID: 39231215
A-to-I RNA editing is a cellular mechanism that generates transcriptomic and proteomic diversity, which is essential for neuronal and immune functions. It involves the conversion of specific adenosines in RNA...
4.
Kiran Kumar K, Singh S, Schmelzle S, Vogel P, Fruhner C, Hanswillemenke A, et al.
Nat Commun
. 2024 Aug;
15(1):6615.
PMID: 39103360
RNA base editing relies on the introduction of adenosine-to-inosine changes into target RNAs in a highly programmable manner in order to repair disease-causing mutations. Here, we propose that RNA base...
5.
Weldy C, Li Q, Monteiro J, Guo H, Galls D, Gu W, et al.
bioRxiv
. 2024 Jul;
PMID: 39026721
One Sentence Summary: Smooth muscle expression of RNA editing enzyme ADAR1 regulates activation of double strand RNA sensor MDA5 in novel mechanism of atherosclerosis.
6.
Hu S, Li J
Curr Opin Genet Dev
. 2024 Apr;
86:102195.
PMID: 38643591
Adenosine-to-inosine RNA editing, catalyzed by the enzymes ADAR1 and ADAR2, stands as a pervasive RNA modification. A primary function of ADAR1-mediated RNA editing lies in labeling endogenous double-stranded RNAs (dsRNAs)...
7.
Jarmoskaite I, Li J
RNA
. 2024 Mar;
30(5):500-511.
PMID: 38531645
Innate immunity must be tightly regulated to enable sensitive pathogen detection while averting autoimmunity triggered by pathogen-like host molecules. A hallmark of viral infection, double-stranded RNAs (dsRNAs) are also abundantly...
8.
Chen L, Ingolia N, Insco M, Li J, Oberdoerffer S, Weeks K
Cell Chem Biol
. 2024 Jan;
31(1):10-13.
PMID: 38242091
In the first of many thematic issues marking the 30 anniversary of Cell Chemical Biology, we highlight the contribution of chemical biology to RNA biology in a special issue on...
9.
Hu S, Heraud-Farlow J, Sun T, Liang Z, Goradia A, Taylor S, et al.
Mol Cell
. 2023 Oct;
83(21):3869-3884.e7.
PMID: 37797622
Effective immunity requires the innate immune system to distinguish foreign nucleic acids from cellular ones. Cellular double-stranded RNAs (dsRNAs) are edited by the RNA-editing enzyme ADAR1 to evade being recognized...
10.
Datta R, Adamska J, Bhate A, Li J
Wiley Interdiscip Rev RNA
. 2023 Sep;
:e1817.
PMID: 37718249
ADAR deaminases catalyze adenosine-to-inosine (A-to-I) editing on double-stranded RNA (dsRNA) substrates that regulate an umbrella of biological processes. One of the two catalytically active ADAR enzymes, ADAR1, plays a major...