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Jin-Xiong She

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Articles 198
Citations 6209
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Recent Articles
51.
Vatanen T, Franzosa E, Schwager R, Tripathi S, Arthur T, Vehik K, et al.
Nature . 2018 Oct; 562(7728):589-594. PMID: 30356183
Type 1 diabetes (T1D) is an autoimmune disease that targets pancreatic islet beta cells and incorporates genetic and environmental factors, including complex genetic elements, patient exposures and the gut microbiome....
52.
Rewers M, Hyoty H, Lernmark A, Hagopian W, She J, Schatz D, et al.
Curr Diab Rep . 2018 Oct; 18(12):136. PMID: 30353256
Purpose Of Review: The environmental triggers of islet autoimmunity leading to type 1 diabetes (T1D) need to be elucidated to inform primary prevention. The Environmental Determinants of Diabetes in the...
53.
Endesfelder D, Zu Castell W, Bonifacio E, Rewers M, Hagopian W, She J, et al.
Diabetes . 2018 Oct; 68(1):119-130. PMID: 30305370
Progression to clinical type 1 diabetes varies among children who develop β-cell autoantibodies. Differences in autoantibody patterns could relate to disease progression and etiology. Here we modeled complex longitudinal autoantibody...
54.
Beyerlein A, Bonifacio E, Vehik K, Hippich M, Winkler C, Frohnert B, et al.
J Med Genet . 2018 Oct; 56(9):602-605. PMID: 30287597
Background: Progression time from islet autoimmunity to clinical type 1 diabetes is highly variable and the extent that genetic factors contribute is unknown. Methods: In 341 islet autoantibody-positive children with...
55.
Lin H, Singla B, Ghoshal P, Faulkner J, Cherian-Shaw M, OConnor P, et al.
Br J Pharmacol . 2018 Jun; 175(18):3640-3655. PMID: 29953580
Background And Purpose: Macropinocytosis is involved in many pathologies, including cardiovascular disorders, cancer, allergic diseases, viral and bacterial infections. Unfortunately, the currently available pharmacological inhibitors of macropinocytosis interrupt other endocytic...
56.
Tailor P, Kodeboyina S, Bai S, Patel N, Sharma S, Ratnani A, et al.
Oncotarget . 2018 May; 9(25):17876-17888. PMID: 29707153
Purpose: The aim of this study was to compare and contrast the expression of all members of the Kallikrein (KLK) family of genes across 15 cancer types and to evaluate...
57.
Bonifacio E, Beyerlein A, Hippich M, Winkler C, Vehik K, Weedon M, et al.
PLoS Med . 2018 Apr; 15(4):e1002548. PMID: 29614081
Background: Around 0.3% of newborns will develop autoimmunity to pancreatic beta cells in childhood and subsequently develop type 1 diabetes before adulthood. Primary prevention of type 1 diabetes will require...
58.
Purohit S, Sharma A, Zhi W, Bai S, Hopkins D, Steed L, et al.
Front Immunol . 2018 Feb; 9:154. PMID: 29445381
Soluble cytokine receptors may play an important role in development of microalbuminuria (MA) in type-1 diabetes (T1D). In this study, we measured 12 soluble receptors and ligands from TNF-α/IL6/IL2 pathways...
59.
Guo D, Xu Q, Pabla S, Koomen J, Biddinger P, Sharma A, et al.
Int J Mol Sci . 2018 Feb; 19(2). PMID: 29443941
Anaplastic thyroid carcinoma (ATC) is almost universally fatal. Elevated keratin-8 (KRT8) protein expression is an established diagnostic cancer biomarker in several epithelial cancers (but not ATC). Several keratins, including KRT8,...
60.
Purohit S, Li T, Guan W, Song X, Song J, Tian Y, et al.
Nat Commun . 2018 Jan; 9(1):258. PMID: 29343722
Glycan-binding proteins (GBPs) play critical roles in diverse cellular functions such as cell adhesion, signal transduction and immune response. Studies of the interaction between GBPs and glycans have been hampered...