Jimmy D Ballard
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Explore the profile of Jimmy D Ballard including associated specialties, affiliations and a list of published articles.
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79
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1658
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Recent Articles
1.
Kempher M, Shadid T, Larabee J, Ballard J
J Bacteriol
. 2024 Jun;
206(7):e0009624.
PMID: 38888328
Importance: is a leading cause of antibiotic associated disease in the United States. The primary virulence factors produced by are two large glucosylating toxins TcdA and TcdB. To date, several...
2.
Norman K, Lang G, Shadid T, Honold S, Reel J, Cox M, et al.
Cell Rep
. 2024 May;
43(5):114245.
PMID: 38761377
Recurrent Clostridioides difficile infection (CDI) results in significant morbidity and mortality. We previously established that CDI in mice does not protect against reinfection and is associated with poor pathogen-specific B...
3.
CSPG4-dependent cytotoxicity for TcdB is influenced by extracellular calcium and chondroitin sulfate
Doyle D, DeAngelis P, Ballard J
mSphere
. 2024 Mar;
9(4):e0009424.
PMID: 38470254
Importance: is a leading cause of antibiotic-associated gastrointestinal illness, and many disease pathologies are caused by the toxin TcdB. TcdB engages multiple cell surface receptors, with receptor tropisms differing among...
4.
Larabee J, Doyle D, Ahmed U, Shadid T, Sharp R, Jones K, et al.
PLoS Pathog
. 2023 Mar;
19(3):e1011272.
PMID: 36972308
The signaling pathways and networks regulating expression of chondroitin sulfate proteoglycan 4 (CSPG4), a cancer-related protein that serves as a receptor for Clostridiodes difficile TcdB, are poorly defined. In this...
5.
Kempher M, Morris S, Shadid T, Menon S, Ballard J, West A
J Bacteriol
. 2022 Jul;
204(8):e0013022.
PMID: 35852332
Two-component signal transduction systems (TCSs), consisting of a sensor histidine kinase (HK) and a response regulator (RR), sense environmental stimuli and then modulate cellular responses, typically through changes in gene...
6.
Pope R, Chitrakar A, Sah P, Shadid T, Ballard J, Zenewicz L
Infect Immun
. 2022 Apr;
90(4):e0007322.
PMID: 35377172
Group 3 innate lymphocytes (ILC3s) are rare immune cells localized in mucosal tissues, especially the gastrointestinal (GI) tract. Despite their rarity, they are a major source of the cytokine interleukin-22...
7.
Lang G, Norman K, Amadou Amani S, Shadid T, Ballard J, Lang M
Front Immunol
. 2022 Jan;
12:818734.
PMID: 35095921
Adjuvant combinations may enhance or broaden the expression of immune responses to vaccine antigens. Information on whether established Alum type adjuvants can be combined with experimental CD1d ligand adjuvants is...
8.
Bishop C, Shadid T, Lavey N, Kempher M, Ballard J, Duerfeldt A
J Bacteriol
. 2021 Nov;
204(2):e0041121.
PMID: 34807726
The Gram-positive bacterium Clostridioides difficile is a primary cause of hospital-acquired diarrhea, threatening both immunocompromised and healthy individuals. An important aspect of defining mechanisms that drive C. difficile persistence and...
9.
Ahmed U, Ballard J
Curr Opin Microbiol
. 2021 Nov;
65:81-86.
PMID: 34773906
The autoinducing peptide-based Agr system in Clostridioides difficile is involved in virulence factor expression, motility, and sporulation. This review highlights several of the recent discoveries regarding C. difficile Agr. Typical...
10.
Lang G, Shrestha B, Amadou Amani S, Shadid T, Ballard J, Lang M
Infect Immun
. 2021 Aug;
89(11):e0043821.
PMID: 34424751
All clinical Clostridioides difficile strains identified to date express a surface capsule-like polysaccharide structure known as polysaccharide II (PSII). The PSII antigen is immunogenic and, when conjugated to a protein...