Jimei Tong
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Explore the profile of Jimei Tong including associated specialties, affiliations and a list of published articles.
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20
Citations
1597
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Recent Articles
1.
Pickles S, Gonzalez Bejarano J, Narayan A, Daughrity L, Maroto Cidfuentes C, Reeves M, et al.
Mov Disord
. 2025 Jan;
PMID: 39788898
Background: Perry syndrome (PS) is a rare and fatal hereditary autosomal dominant neurodegenerative disorder caused by mutations in dynactin (DCTN1). PS brains accumulate inclusions positive for ubiquitin, transactive-response DNA-binding protein...
2.
Pickles S, Zanetti Alepuz D, Koike Y, Yue M, Tong J, Liu P, et al.
Front Cell Dev Biol
. 2023 Aug;
11:1251551.
PMID: 37614226
Treatments for neurodegenerative disease, including Frontotemporal dementia (FTD) and Amyotrophic lateral sclerosis (ALS), remain rather limited, underscoring the need for greater mechanistic insight and disease-relevant models. Our ability to develop...
3.
Park J, Wu Y, Shao W, Gendron T, van der Spek S, Sultanakhmetov G, et al.
Cell Rep
. 2023 Jul;
42(8):112822.
PMID: 37471224
C9orf72 repeat expansions are the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Poly(GR) proteins are toxic to neurons by forming cytoplasmic inclusions that sequester...
4.
Shao W, Todd T, Wu Y, Jones C, Tong J, Jansen-West K, et al.
Science
. 2022 Oct;
378(6615):94-99.
PMID: 36201573
Frontotemporal dementia and amyotrophic lateral sclerosis (FTD-ALS) are associated with both a repeat expansion in the gene and mutations in the TANK-binding kinase 1 () gene. We found that TBK1...
5.
Jansen-West K, Todd T, Daughrity L, Yue M, Tong J, Carlomagno Y, et al.
Front Cell Dev Biol
. 2022 Apr;
10:863089.
PMID: 35386195
Spinocerebellar ataxia type 3 (SCA3) is a dominantly inherited cerebellar ataxia caused by the expansion of a polyglutamine (polyQ) repeat in the gene encoding ATXN3. The polyQ expansion induces protein...
6.
Del Rosso G, Carlomagno Y, Todd T, Jones C, Prudencio M, Daughrity L, et al.
Front Cell Dev Biol
. 2022 Jan;
9:809942.
PMID: 35096836
The aberrant translation of a repeat expansion in chromosome 9 open reading frame 72 (), the most common cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), results in...
7.
Wu Y, Shao W, Todd T, Tong J, Yue M, Koga S, et al.
Cell Rep
. 2021 Aug;
36(8):109581.
PMID: 34433069
Loss-of-function mutations in the progranulin gene (GRN), which encodes progranulin (PGRN), are a major cause of frontotemporal dementia (FTD). GRN-associated FTD is characterized by TDP-43 inclusions and neuroinflammation, but how...
8.
Cook C, Wu Y, Odeh H, Gendron T, Jansen-West K, Del Rosso G, et al.
Sci Transl Med
. 2020 Sep;
12(559).
PMID: 32878979
TAR DNA-binding protein 43 (TDP-43) inclusions are a pathological hallmark of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), including cases caused by GC repeat expansions in the gene (c9FTD/ALS)....
9.
Todd T, McEachin Z, Chew J, Burch A, Jansen-West K, Tong J, et al.
Cell Rep
. 2020 May;
31(5):107616.
PMID: 32375043
A GC hexanucleotide repeat expansion in an intron of C9orf72 is the most common cause of frontal temporal dementia and amyotrophic lateral sclerosis (c9FTD/ALS). A remarkably similar intronic TGC repeat...
10.
Zhang Y, Guo L, Gonzales P, Gendron T, Wu Y, Jansen-West K, et al.
Science
. 2019 Feb;
363(6428).
PMID: 30765536
How hexanucleotide GGGGCC (GC) repeat expansions in cause frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) is not understood. We developed a mouse model engineered to express poly(PR), a proline-arginine...