Jim E Brandle
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Explore the profile of Jim E Brandle including associated specialties, affiliations and a list of published articles.
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12
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274
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Recent Articles
1.
Chen L, Dempsey B, Gyenis L, Menassa R, Brandle J, Dhaubhadel S
Plant Biotechnol J
. 2013 Jan;
11(5):546-54.
PMID: 23301867
Plants are one of the most economical platforms for large-scale production of recombinant proteins for biopharmaceutical and industrial uses. A large number of human recombinant proteins of therapeutic value have...
2.
Conley A, Zhu H, Le L, Jevnikar A, Lee B, Brandle J, et al.
Plant Biotechnol J
. 2010 Nov;
9(4):434-44.
PMID: 21040385
Although many different crop species have been used to produce a wide range of vaccines, antibodies, biopharmaceuticals and industrial enzymes, tobacco has the most established history for the production of...
3.
Joensuu J, Conley A, Lienemann M, Brandle J, Linder M, Menassa R
Plant Physiol
. 2009 Dec;
152(2):622-33.
PMID: 20018596
Insufficient accumulation levels of recombinant proteins in plants and the lack of efficient purification methods for recovering these valuable proteins have hindered the development of plant biotechnology applications. Hydrophobins are...
4.
Conley A, Joensuu J, Menassa R, Brandle J
BMC Biol
. 2009 Aug;
7:48.
PMID: 19664215
Background: Elastin-like polypeptides are synthetic biopolymers composed of a repeating pentapeptide 'VPGXG' sequence that are valuable for the simple non-chromatographic purification of recombinant proteins. In addition, elastin-like polypeptide fusions have...
5.
Conley A, Jevnikar A, Menassa R, Brandle J
Transgenic Res
. 2009 Jul;
19(2):291-8.
PMID: 19618287
Plants have shown promise as bioreactors for the large-scale production of a wide variety of recombinant proteins. To increase the economic feasibility of this technology, numerous molecular approaches have been...
6.
Ge X, Conley A, Brandle J, Truant R, Filipe C
J Am Chem Soc
. 2009 Jun;
131(25):9094-9.
PMID: 19496598
In this paper, we report the formation of protein based liquid droplets resulting in the formation of in vivo microcompartments in E. coli or tobacco cells. These microcompartments were generated...
7.
Conley A, Joensuu J, Jevnikar A, Menassa R, Brandle J
Biotechnol Bioeng
. 2009 Mar;
103(3):562-73.
PMID: 19266472
The demand for recombinant proteins for medical and industrial use is expanding rapidly and plants are now recognized as an efficient, inexpensive means of production. Although the accumulation of recombinant...
8.
Conley A, Mohib K, Jevnikar A, Brandle J
Plant Biotechnol J
. 2008 Dec;
7(2):183-99.
PMID: 19055608
Human erythropoietin (EPO) is a pleiotropic cytokine with remarkable tissue-protective activities in addition to its well-established role in red blood cell production. Unfortunately, conventional mammalian cell cultures are unlikely to...
9.
Almquist K, Niu Y, McLean M, Mena F, Yau K, Brown K, et al.
Plant Biotechnol J
. 2006 Dec;
2(3):189-97.
PMID: 17147610
In order to create a novel mechanism for herbicide resistance in plants, we expressed a single-chain antibody fragment (scFv) in tobacco with specific affinity to the auxinic herbicide picloram. Transgenic...
10.
Murata J, Bienzle D, Brandle J, Sensen C, De Luca V
FEBS Lett
. 2006 Jul;
580(18):4501-7.
PMID: 16870181
The Madagascar periwinkle (Catharanthus roseus) is well known to produce the chemotherapeutic anticancer agents, vinblastine and vincristine. In spite of its importance, no expressed sequence tag (EST) analysis of this...