Michael D McLean
Overview
Explore the profile of Michael D McLean including associated specialties, affiliations and a list of published articles.
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30
Citations
330
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Recent Articles
1.
Prudhomme N, Pastora R, Thomson S, Zheng E, Sproule A, Krieger J, et al.
Plant Biotechnol J
. 2024 Mar;
22(8):2248-2266.
PMID: 38516995
The need for therapeutics to treat a plethora of medical conditions and diseases is on the rise and the demand for alternative approaches to mammalian-based production systems is increasing. Plant-based...
2.
Prudhomme N, Krieger J, McLean M, Cossar D, Geddes-McAlister J
Methods Mol Biol
. 2022 May;
2456:275-286.
PMID: 35612749
Transient expression of recombinant proteins in plants is being used as a platform for production of therapeutic proteins. Benefits of this system include a reduced cost of drug development, rapid...
3.
Geddes-McAlister J, Prudhomme N, Gutierrez Gongora D, Cossar D, McLean M
Curr Opin Chem Biol
. 2022 Apr;
68:102133.
PMID: 35378382
Molecular pharming relies on the integration of foreign genes into a plant system for production of the desired recombinant protein. The speed, scalability, and lack of contaminating human pathogens highlights...
4.
Anand S, Ding S, Tolbert W, Prevost J, Richard J, Gil H, et al.
J Virol
. 2021 Jul;
95(18):e0079621.
PMID: 34232070
The activity of broadly neutralizing antibodies (bNAbs) targeting HIV-1 depends on pleiotropic functions, including viral neutralization and the elimination of HIV-1-infected cells. Several studies have suggested that passive administration of...
5.
Moretti M, Van Horn C, Robertson R, Segobye K, Weller S, Young B, et al.
Pest Manag Sci
. 2017 Mar;
74(5):1079-1088.
PMID: 28276187
Background: The glyphosate-resistant rapid response (GR RR) resistance mechanism in Ambrosia trifida is not due to target-site resistance (TSR) mechanisms. This study explores the physiology of the rapid response and...
6.
Van Horn C, Moretti M, Robertson R, Segobye K, Weller S, Young B, et al.
Pest Manag Sci
. 2017 Mar;
74(5):1071-1078.
PMID: 28266132
Background: Glyphosate-resistant (GR) Ambrosia trifida is now present in the midwestern United States and in southwestern Ontario, Canada. Two distinct GR phenotypes are known, including a rapid response (GR RR)...
7.
Topp E, Irwin R, McAllister T, Lessard M, Joensuu J, Kolotilin I, et al.
Biotechnol Adv
. 2016 Feb;
34(5):597-604.
PMID: 26875776
The excessive use of antibiotics in food animal production has contributed to resistance in pathogenic bacteria, thereby triggering regulations and consumer demands to limit their use. Alternatives for disease control...
8.
MacDonald J, Doshi K, Dussault M, Hall J, Holbrook L, Jones G, et al.
Biotechnol Adv
. 2015 Aug;
33(8):1572-81.
PMID: 26232717
The production of recombinant vaccines in plants may help to reduce the burden of veterinary diseases, which cause major economic losses and in some cases can affect human health. While...
9.
Kolotilin I, Topp E, Cox E, Devriendt B, Conrad U, Joensuu J, et al.
Vet Res
. 2015 Jan;
45:117.
PMID: 25559098
An alarming increase in emergence of antibiotic resistance among pathogens worldwide has become a serious threat to our ability to treat infectious diseases according to the World Health Organization. Extensive...
10.
Richard G, Meyers A, McLean M, Arbabi-Ghahroudi M, MacKenzie R, Hall J
PLoS One
. 2013 Jul;
8(7):e69495.
PMID: 23894495
Small recombinant antibody fragments (e.g. scFvs and VHHs), which are highly tissue permeable, are being investigated for antivenom production as conventional antivenoms consisting of IgG or F(ab')2 antibody fragments do...