Jill H Fowler
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Explore the profile of Jill H Fowler including associated specialties, affiliations and a list of published articles.
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21
Citations
706
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Recent Articles
1.
Molina-Gonzalez I, Holloway R, Jiwaji Z, Dando O, Kent S, Emelianova K, et al.
Nat Commun
. 2023 Jun;
14(1):3372.
PMID: 37291151
Failed regeneration of myelin around neuronal axons following central nervous system damage contributes to nerve dysfunction and clinical decline in various neurological conditions, for which there is an unmet therapeutic...
2.
Sigfridsson E, Marangoni M, Hardingham G, Horsburgh K, Fowler J
J Neuroinflammation
. 2020 Dec;
17(1):367.
PMID: 33261626
Background: Chronic cerebral hypoperfusion causes damage to the brain's white matter underpinning vascular cognitive impairment. Inflammation and oxidative stress have been proposed as key pathophysiological mechanisms of which the transcription...
3.
Fowler J, Kalaria R
Brain Commun
. 2020 Sep;
2(2):fcaa067.
PMID: 32954324
This scientific commentary refers to 'Structural brain networks and functional motor outcome after stroke -a prospective cohort study', by Schlemm (https://doi.org/10.1093/braincomms/fcaa001) in and 'Brain responsivity provides an individual readout for...
4.
Qiu J, Dando O, Febery J, Fowler J, Chandran S, Hardingham G
Int J Mol Sci
. 2020 Mar;
21(6).
PMID: 32178355
Forebrain neurons have relatively weak intrinsic antioxidant defenses compared to astrocytes, in part due to hypo-expression of Nrf2, an oxidative stress-induced master regulator of antioxidant and detoxification genes. Nevertheless, neurons...
5.
McFall A, Hietamies T, Bernard A, Aimable M, Allan S, Bath P, et al.
J Cereb Blood Flow Metab
. 2020 Mar;
40(7):1402-1414.
PMID: 32151228
Assessment of outcome in preclinical studies of vascular cognitive impairment (VCI) is heterogenous. Through an ARUK Scottish Network supported questionnaire and workshop (mostly UK-based researchers), we aimed to determine underlying...
6.
Sigfridsson E, Marangoni M, Johnson J, Hardingham G, Fowler J, Horsburgh K
Sci Rep
. 2018 Aug;
8(1):12552.
PMID: 30135571
Mouse models have shown that cerebral hypoperfusion causes white matter disruption and memory impairment relevant to the study of vascular cognitive impairment and dementia. The associated mechanisms include inflammation and...
7.
Horsburgh K, Wardlaw J, Van Agtmael T, Allan S, Ashford M, Bath P, et al.
Clin Sci (Lond)
. 2018 May;
132(8):851-868.
PMID: 29712883
Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve...
8.
Fowler J, McQueen J, Holland P, Manso Y, Marangoni M, Scott F, et al.
J Cereb Blood Flow Metab
. 2017 Jun;
38(8):1354-1370.
PMID: 28606007
The brain's white matter is highly vulnerable to reductions in cerebral blood flow via mechanisms that may involve elevated microgliosis and pro-inflammatory pathways. In the present study, the effects of...
9.
McQueen J, Reimer M, Holland P, Manso Y, McLaughlin M, Fowler J, et al.
PLoS One
. 2014 Feb;
9(2):e87227.
PMID: 24498301
Chronic cerebral hypoperfusion, a sustained modest reduction in cerebral blood flow, is associated with damage to myelinated axons and cognitive decline with ageing. Oligodendrocytes (the myelin producing cells) and their...
10.
Martel M, Ryan T, Bell K, Fowler J, McMahon A, Al-Mubarak B, et al.
Neuron
. 2012 May;
74(3):543-56.
PMID: 22578505
It is currently unclear whether the GluN2 subtype influences NMDA receptor (NMDAR) excitotoxicity. We report that the toxicity of NMDAR-mediated Ca(2+) influx is differentially controlled by the cytoplasmic C-terminal domains...