Siddharthan Chandran
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Explore the profile of Siddharthan Chandran including associated specialties, affiliations and a list of published articles.
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245
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7530
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Recent Articles
1.
Ramesh V, Tsoukala E, Kougianou I, Kozic Z, Burr K, Viswanath B, et al.
Glia
. 2025 Feb;
PMID: 39928301
The Fragile X Messenger Ribonucleoprotein (FMRP) is an RNA binding protein that regulates the translation of multiple mRNAs and is expressed by neurons and glia in the mammalian brain. Loss...
2.
De Decker M, Zelina P, Moens T, Beckers J, Contardo M, Dittlau K, et al.
Brain
. 2024 Dec;
148(3):803-816.
PMID: 39703094
Progressive loss of motor neurons is the hallmark of the neurodegenerative disease amyotrophic lateral sclerosis (ALS), but the underlying disease mechanisms remain incompletely understood. In this study, we investigate the...
3.
De Angelis F, Cameron J, Eshaghi A, Parker R, Connick P, Stutters J, et al.
J Neurol Neurosurg Psychiatry
. 2024 Dec;
PMID: 39694820
Background: Optical coherence tomography (OCT) inner retinal metrics reflect neurodegeneration in multiple sclerosis (MS). We explored OCT measures as biomarkers of disease severity in secondary progressive MS (SPMS). Methods: We...
4.
Heffernan A, Steinruecke M, Dempsey G, Chandran S, Selvaraj B, Jiwaji Z, et al.
Mol Psychiatry
. 2024 Oct;
30(3):1138-1147.
PMID: 39463449
Delirium is a common acute onset neurological syndrome characterised by transient fluctuations in cognition. It affects over 20% of medical inpatients and 50% of those critically ill. Delirium is associated...
5.
Saez-Atienzar S, Souza C, Chia R, Beal S, Lorenzini I, Huang R, et al.
Cell Genom
. 2024 Oct;
4(11):100679.
PMID: 39437787
Repeat expansions in the C9orf72 gene are the most common genetic cause of (ALS) and frontotemporal dementia (FTD). Like other genetic forms of neurodegeneration, pinpointing the precise mechanism(s) by which...
6.
Gillespie D, Sacripante R, Chandran S, Foley P
Mult Scler Relat Disord
. 2024 Oct;
91:105904.
PMID: 39396480
Introduction: Suicidal ideation (SI) is common in people with multiple sclerosis (pwMS) who have longstanding illness. Prevalence of SI in the weeks to months following diagnosis is unknown, as are...
7.
Fatigue in early multiple sclerosis: MRI metrics of neuroinflammation, relapse and neurodegeneration
Meijboom R, Foley P, MacDougall N, Mina Y, York E, Kampaite A, et al.
Brain Commun
. 2024 Oct;
6(5):fcae278.
PMID: 39386090
Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease affecting the brain and spinal cord. Fatigue is a common disabling symptom from MS onset, however the mechanisms by which underlying...
8.
Hutchings A, Hambrecht B, Veh A, Giridhar N, Zare A, Angerer C, et al.
Nat Commun
. 2024 Oct;
15(1):8622.
PMID: 39366938
Increasing evidence suggests an essential function for autophagy in unconventional protein secretion (UPS). However, despite its relevance for the secretion of aggregate-prone proteins, the mechanisms of secretory autophagy in neurons...
9.
Quail N, Leighton D, Newton J, Davidson S, Kelly L, McKeown A, et al.
J Palliat Care
. 2024 Sep;
40(1):89-97.
PMID: 39344431
Motor neuron disease is a rapidly progressing neurological condition. People with life-limiting conditions generally prefer to die at home and avoid hospital admissions, with Specialist Palliative Care Team involvement often...
10.
Pal S, Chataway J, Swingler R, Macleod M, Carragher N, Hardingham G, et al.
Lancet Neurol
. 2024 Sep;
23(11):1097-1107.
PMID: 39307154
Background: Motor neuron disease represents a group of progressive and incurable diseases that are characterised by selective loss of motor neurons, resulting in an urgent need for rapid identification of...