Jill E Kucab
Overview
Explore the profile of Jill E Kucab including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
22
Citations
790
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Caipa Garcia A, Kucab J, Al-Serori H, Beck R, Bellamri M, Turesky R, et al.
Chem Res Toxicol
. 2024 Jan;
37(2):234-247.
PMID: 38232180
Human tissue three-dimensional (3D) organoid cultures have the potential to reproduce the physiological properties and cellular architecture of the organs from which they are derived. The ability of organoid cultures...
2.
Caipa Garcia A, Kucab J, Al-Serori H, Beck R, Fischer F, Hufnagel M, et al.
Int J Mol Sci
. 2023 Jan;
24(1).
PMID: 36614051
Organoids are 3D cultures that to some extent reproduce the structure, composition and function of the mammalian tissues from which they derive, thereby creating in vitro systems with more in...
3.
Holzl-Armstrong L, Kucab J, Zwart E, Luijten M, Phillips D, Arlt V
Environ Mol Mutagen
. 2021 Feb;
62(4):252-264.
PMID: 33620775
TP53 harbors somatic mutations in more than half of human tumors with some showing characteristic mutation spectra that have been linked to environmental exposures. In bladder cancer, a unique distribution...
4.
Holzl-Armstrong L, Moody S, Kucab J, Zwart E, Bellamri M, Luijten M, et al.
Food Chem Toxicol
. 2020 Nov;
147:111855.
PMID: 33189884
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a possible human carcinogen formed in cooked fish and meat. PhIP is bioactivated by cytochrome P450 enzymes to form 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP), a genotoxic metabolite that reacts with...
5.
Holzl-Armstrong L, Kucab J, Moody S, Zwart E, Loutkotova L, Duffy V, et al.
Arch Toxicol
. 2020 Sep;
94(12):4173-4196.
PMID: 32886187
Acrylamide is a suspected human carcinogen formed during high-temperature cooking of starch-rich foods. It is metabolised by cytochrome P450 2E1 to its reactive metabolite glycidamide, which forms pre-mutagenic DNA adducts....
6.
Holzl-Armstrong L, Kucab J, Korenjak M, Luijten M, Phillips D, Zavadil J, et al.
Methods Protoc
. 2019 Nov;
2(4).
PMID: 31766274
DNA in dividing cells is prone to mutagenesis, with mutations making key contributions to human disease including cancer. The tumour suppressor gene is the most frequently mutated gene in human...
7.
Kucab J, Zou X, Morganella S, Joel M, Nanda A, Nagy E, et al.
Cell
. 2019 Apr;
177(4):821-836.e16.
PMID: 30982602
Whole-genome-sequencing (WGS) of human tumors has revealed distinct mutation patterns that hint at the causative origins of cancer. We examined mutational signatures in 324 WGS human-induced pluripotent stem cells exposed...
8.
Kucab J, Hollstein M, Arlt V, Phillips D
Int J Cancer
. 2016 Nov;
140(4):877-887.
PMID: 27813088
TP53 mutations occur in half of all human tumours. Mutagen-induced or spontaneous TP53 mutagenesis can be studied in vitro using the human TP53 knock-in (Hupki) mouse embryo fibroblast (HUF) immortalisation...
9.
Kucab J, Zwart E, van Steeg H, Luijten M, Schmeiser H, Phillips D, et al.
DNA Repair (Amst)
. 2016 Jan;
39:21-33.
PMID: 26723900
3-Nitrobenzanthrone (3-NBA) is a highly mutagenic compound and possible human carcinogen found in diesel exhaust. 3-NBA forms bulky DNA adducts following metabolic activation and induces predominantly G:CT:A transversions in a...
10.
Nik-Zainal S, Kucab J, Morganella S, Glodzik D, Alexandrov L, Arlt V, et al.
Mutagenesis
. 2015 Oct;
30(6):763-70.
PMID: 26443852
Whole genome sequencing of human tumours has revealed distinct patterns of mutation that hint at the causative origins of cancer. Experimental investigations of the mutations and mutation spectra induced by...