Jill E Clampit
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Explore the profile of Jill E Clampit including associated specialties, affiliations and a list of published articles.
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12
Citations
323
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Recent Articles
1.
Comess K, Sun C, Abad-Zapatero C, Goedken E, Gum R, Borhani D, et al.
ACS Chem Biol
. 2010 Nov;
6(3):234-44.
PMID: 21090814
Inhibition of protein kinases has validated therapeutic utility for cancer, with at least seven kinase inhibitor drugs on the market. Protein kinase inhibition also has significant potential for a variety...
2.
Liu M, Wang S, Clampit J, Gum R, Haasch D, Rondinone C, et al.
Bioorg Med Chem Lett
. 2006 Nov;
17(3):668-72.
PMID: 17107797
A new series of 4-anilinopyrimidines has been synthesized and evaluated as JNK1 inhibitors. SAR studies led to the discovery of potent JNK1 inhibitors with good enzymatic activity as well as...
3.
Gonzalez-Rodriguez A, Clampit J, Escribano O, Benito M, Rondinone C, Valverde A
Endocrinology
. 2006 Oct;
148(2):594-608.
PMID: 17068137
Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin signaling and a therapeutic target for type 2 diabetes. The purpose of this study was to evaluate the differences...
4.
Liu G, Zhao H, Liu B, Xin Z, Liu M, Kosogof C, et al.
Bioorg Med Chem Lett
. 2006 Sep;
16(22):5723-30.
PMID: 16971120
The structure-activity relationships of 5,6-positions of aminopyridine carboxamide-based c-Jun N-terminal Kinase (JNK) inhibitors were explored to expand interaction with the kinase specificity and ribose-binding pockets. The syntheses of analogues and...
5.
Zhao H, Serby M, Xin Z, Szczepankiewicz B, Liu M, Kosogof C, et al.
J Med Chem
. 2006 Jul;
49(15):4455-8.
PMID: 16854050
C-Jun NH2 terminal kinases (JNKs) are important cell signaling enzymes. JNK1 plays a central role in linking obesity and insulin resistance. JNK2 and JNK3 may be involved in inflammatory and...
6.
Szczepankiewicz B, Kosogof C, Nelson L, Liu G, Liu B, Zhao H, et al.
J Med Chem
. 2006 Jun;
49(12):3563-80.
PMID: 16759099
The c-Jun N-terminal kinases (JNK-1, -2, and -3) are members of the mitogen activated protein (MAP) kinase family of enzymes. They are activated in response to certain cytokines, as well...
7.
Haasch D, Berg C, Clampit J, Pederson T, Frost L, Kroeger P, et al.
Biochem Biophys Res Commun
. 2006 Mar;
343(2):361-8.
PMID: 16545776
Activation of PKCtheta is associated with lipid-induced insulin resistance and PKCtheta knockout mice are protected from the lipid-induced defects. However, the exact mechanism by which PKCtheta contributes to insulin resistance...
8.
Liu M, Xin Z, Clampit J, Wang S, Gum R, Haasch D, et al.
Bioorg Med Chem Lett
. 2006 Mar;
16(10):2590-4.
PMID: 16527482
A novel class of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as c-Jun-N-terminal kinase (JNK) inhibitors is described. These compounds were synthesized via the condensation of 2-nitrobenzaldehydes and hydroxypyrazoles. The structure-activity relationships (SAR) and kinase selectivity...
9.
Waring J, Ciurlionis R, Clampit J, Morgan S, Gum R, Jolly R, et al.
Mol Cell Endocrinol
. 2003 Jun;
203(1-2):155-68.
PMID: 12782412
Protein tyrosine phosphatases are important regulators of insulin signal transduction. Our studies have shown that in insulin resistant and diabetic ob/ob and db/db mice, reducing the levels of protein tyrosine...
10.
Clampit J, Meuth J, Smith H, Reilly R, Jirousek M, Trevillyan J, et al.
Biochem Biophys Res Commun
. 2002 Dec;
300(2):261-7.
PMID: 12504077
Protein-tyrosine phosphatase-1B (PTP1B) has been implicated as a negative regulator of insulin signaling. PTP1B dephosphorylates the insulin receptor and insulin receptor substrates (IRS-1/2), inhibiting the insulin-signaling pathway. PTP1B has been...