Jian Zhan
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Explore the profile of Jian Zhan including associated specialties, affiliations and a list of published articles.
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Articles
78
Citations
886
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Recent Articles
1.
Ren Y, Lin X, Liao W, Peng X, Deng J, Zhang Z, et al.
Nucleic Acids Res
. 2024 Dec;
53(3).
PMID: 39721592
X-ray crystallography is a fundamental technique that provides atomic-level insights into RNA structures. However, obtaining crystals of RNA structures diffracting to high resolution is challenging. We introduce a simple strategy...
2.
Ning Y, Zhang Y, Jiang T, Feng J, Zhan J, Ou C, et al.
Neurosci Res
. 2024 Dec;
212:84-96.
PMID: 39674403
Trigeminal neuralgia (TN) is a prevalent chronic neuropathic pain syndrome characterized by severe pain, often accompanied by cognitive dysfunction and cerebral degeneration. However, its mechanisms remain poorly understood. Hyperphosphorylation of...
3.
Zhang Z, Hong X, Xiong P, Wang J, Zhou Y, Zhan J
Elife
. 2024 Dec;
12.
PMID: 39636683
Despite their importance in a wide range of living organisms, self-cleaving ribozymes in the human genome are few and poorly studied. Here, we performed deep mutational scanning and covariance analysis...
4.
Chen K, Litfin T, Singh J, Zhan J, Zhou Y
Genomics Proteomics Bioinformatics
. 2024 Jun;
22(1).
PMID: 38872612
Recent success of AlphaFold2 in protein structure prediction relied heavily on co-evolutionary information derived from homologous protein sequences found in the huge, integrated database of protein sequences (Big Fantastic Database)....
5.
Rao X, Zhou K, Tu J, Lei Y, Li Q, Hong X, et al.
Biochem Biophys Res Commun
. 2024 Jun;
724:150224.
PMID: 38851139
Despite intensive search over the past decades, only a few small-molecule DNA fluorescent dyes were found with large Stokes shifts. These molecules, however, are often too toxic for widespread usage....
6.
Wu S, Lai H, Sanjib Banerjee N, Ma Z, Santana J, Wei S, et al.
Mol Cell
. 2023 Dec;
84(2):202-220.e15.
PMID: 38103559
Compounds binding to the bromodomains of bromodomain and extra-terminal (BET) family proteins, particularly BRD4, are promising anticancer agents. Nevertheless, side effects and drug resistance pose significant obstacles in BET-based therapeutics...
7.
Zhang X, Yin H, Ling F, Zhan J, Zhou Y
PLoS Comput Biol
. 2023 Dec;
19(12):e1011330.
PMID: 38060617
Recent advances in deep learning have significantly improved the ability to infer protein sequences directly from protein structures for the fix-backbone design. The methods have evolved from the early use...
8.
Zhou Y, Litfin T, Zhan J
Natl Sci Rev
. 2023 Nov;
10(12):nwad259.
PMID: 38033736
No abstract available.
9.
Zhang Y, Lang M, Jiang J, Gao Z, Xu F, Litfin T, et al.
Nucleic Acids Res
. 2023 Nov;
52(1):e3.
PMID: 37941140
Compared with proteins, DNA and RNA are more difficult languages to interpret because four-letter coded DNA/RNA sequences have less information content than 20-letter coded protein sequences. While BERT (Bidirectional Encoder...
10.
Zhan J, Yuan J, Liu J, Zhang F, Yu F, Wang Y
Mycology
. 2023 Aug;
14(3):264-274.
PMID: 37583453
The genus has high edible and medical values, with zones of antagonism often occurring when different species are paired in culture on agar media, while the antagonism-induced metabolic alteration remains...