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Jiami Guo

Explore the profile of Jiami Guo including associated specialties, affiliations and a list of published articles. Areas
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Articles 23
Citations 686
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Recent Articles
1.
Shen Z, Guo J, Lu Y
Nat Commun . 2024 Sep; 15(1):8351. PMID: 39333126
The development of a new catalytic asymmetric synthetic methodology has been following virtually the same pattern in the past decades. Herein, we present a latent synthon strategy within this well-established...
2.
Wang L, Guo Q, Acharya S, Zheng X, Huynh V, Whitmore B, et al.
Nat Neurosci . 2024 Aug; 27(9):1708-1720. PMID: 39103557
Astrocyte diversity is greatly influenced by local environmental modulation. Here we report that the majority of astrocytes across the mouse brain possess a singular primary cilium localized to the cell...
3.
Tan X, He Y, Yu P, Deng Y, Xie Z, Guo J, et al.
Mol Med . 2024 Jul; 30(1):102. PMID: 39009982
Background: Acute monocytic leukemia-M5 (AML-M5) remains a challenging disease due to its high morbidity and poor prognosis. In addition to the evidence mentioned earlier, several studies have shown that programmed...
4.
Dai L, Zhou X, Guo J, Huang Q, Lu Y
Chem Sci . 2024 Apr; 15(16):5993-6001. PMID: 38665510
Axially chiral molecular scaffolds are widely present in therapeutic agents, natural products, catalysts, and advanced materials. The construction of such molecules has garnered significant attention from academia and industry. The...
5.
Zhou X, Huang Q, Guo J, Dai L, Lu Y
Adv Sci (Weinh) . 2024 Apr; 11(24):e2309645. PMID: 38650176
Chiral aldehydes containing a tertiary stereogenic center are versatile building blocks in organic chemistry. In particular, such structural motifs bearing an α,α-diaryl moiety are very challenging scaffolds and their efficient...
6.
Wu J, Cho S, Descant K, Li P, Shapson-Coe A, Januszewski M, et al.
Neuron . 2023 Oct; 112(1):41-55.e3. PMID: 37898123
Primary cilia act as antenna receivers of environmental signals and enable effective neuronal or glial responses. Disruption of their function is associated with circuit disorders. To understand the signals these...
7.
Zhou X, Huang Q, Guo J, Dai L, Lu Y
ACS Cent Sci . 2023 Oct; 9(9):1758-1767. PMID: 37780359
Heterocyclic scaffolds are commonly found in numerous biologically active molecules, therapeutic agents, and agrochemicals. To probe chemical space around heterocycles, many powerful molecular editing strategies have been devised. Versatile C-H...
8.
Zhou X, Huang Q, Guo J, Dai L, Lu Y
Angew Chem Int Ed Engl . 2023 Sep; 62(45):e202310078. PMID: 37724448
Chiral α,α-diaryl ketones are structural motifs commonly present in bioactive molecules, and they are also valuable building blocks in synthetic organic chemistry. However, catalytic asymmetric synthesis of α,α-diaryl ketones bearing...
9.
Dai L, Zhou X, Guo J, Dai X, Huang Q, Lu Y
Nat Commun . 2023 Aug; 14(1):4813. PMID: 37558716
The C-N axially chiral N-arylpyrrole motifs are privileged scaffolds in numerous biologically active molecules and natural products, as well as in chiral ligands/catalysts. Asymmetric synthesis of N-arylpyrroles, however, is still...
10.
Dai L, Guo J, Huang Q, Lu Y
Sci Adv . 2022 Sep; 8(37):eadd2574. PMID: 36103531
Alkynes represent a family of pivotal and sustainable feedstocks for various industries such as pharmaceuticals, agrochemicals, and materials, and they are widely used as important starting materials for the production...