Jiadai Liu
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Explore the profile of Jiadai Liu including associated specialties, affiliations and a list of published articles.
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21
Citations
45
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Recent Articles
1.
Yao H, Ren Y, Wu F, Cao L, Liu J, Yan M, et al.
J Med Chem
. 2024 Dec;
68(1):465-490.
PMID: 39711508
In this study, we discovered and identified a novel AXL/triple angiokinase inhibitor by rational structural modification based on the structure of triple angiokinase inhibitor Nintedanib. We found that potently inhibited...
2.
Liu J, Li E, Li X, Wang X, Huang Q, Wang H, et al.
Anim Nutr
. 2024 Dec;
19:226-239.
PMID: 39635418
This study investigated the effects of dietary methionine (Met) on growth performance and protein synthesis in juvenile Chinese mitten crabs () fed fish meal (FM)-free diets. Three diets free of...
3.
Liu J, Chen Y
Am J Physiol Endocrinol Metab
. 2024 Jul;
327(3):E371-E383.
PMID: 39082899
Obesity is a metabolic disorder with pandemic-like implications, lacking viable pharmaceutical treatments currently. Thermogenic adipose tissues, including brown and beige adipose tissues, play an essential role in regulating systemic energy...
4.
Yao H, Ren Y, Wu F, Liu J, Li J, Cao L, et al.
Eur J Med Chem
. 2024 Jun;
275:116590.
PMID: 38908104
The C797S mutation of EGFR leads to Osimertinib resistance by blocking the covalent binding of Cys797. To develop new agents that can overcome EGFR mutation resistance, thirty seven new cyclopropane...
5.
Yao H, Ren Y, Wu F, Liu J, Cao L, Yan M, et al.
RSC Adv
. 2024 Jun;
14(25):17557-17570.
PMID: 38828277
With ceritinib as the lead, a series of novel compounds containing the sulfoxide structure were synthesized and evaluated as anaplastic lymphoma kinase inhibitors. Among them, compounds 18a-d exhibited excellent anti-proliferation...
6.
Liu J, Nie W, Nie H, Yao H, Ren Y, Cao L, et al.
Bioorg Chem
. 2024 Mar;
146:107313.
PMID: 38554675
A series of new deuterated and non-deuterated N, N-diphenylpyridine - 2,4-diamine derivatives were synthesized and evaluated as EGFR C797S-mediated resistance inhibitors. Most of these compounds exhibited potent antiproliferative activity against...
7.
Liu S, Yu Q, Liu J, Wang H, Wang X, Qin C, et al.
Fish Shellfish Immunol
. 2024 Feb;
147:109455.
PMID: 38369072
As a fat-soluble vitamin, vitamin D relies on fat to perform its biological function, affecting lipid metabolism and innate immunity. This study used different percentages of lipid and vitamin D...
8.
Wang H, Li E, Huang Q, Liu J, Miao Y, Wang X, et al.
Aquac Nutr
. 2024 Jan;
2024:6625061.
PMID: 38292025
A 56-day feeding trial assessed the effects of black soldier fly larvae meal (BSFLM) on the growth performance and hepatopancreas health of juvenile . Six isoproteic and isolipidic diets with...
9.
An B, Nie W, Hu J, Fan Y, Nie H, Wang M, et al.
Cell Death Dis
. 2023 Nov;
14(11):728.
PMID: 37945598
Multiple tumors are synergistically promoted by c-Met and TRK, and blocking their cross-signalling pathway may give better effects. In this study, we developed a tyrosine kinase inhibitor 1D228, which exhibited...
10.
Pan R, Liu J, Chen Y
Front Pharmacol
. 2023 Jul;
14:1144918.
PMID: 37435495
Diabetes mellitus is mainly classified into four types according to its pathogenesis, of which type 2 diabetes mellitus (T2DM) has the highest incidence rate and is most relevant to obesity....