Jia Tong Loh
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Explore the profile of Jia Tong Loh including associated specialties, affiliations and a list of published articles.
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15
Citations
235
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Recent Articles
1.
Loh J, Teo J, Kannan S, Verma C, Andiappan A, Lim H, et al.
Sci Signal
. 2023 Oct;
16(809):eadg5171.
PMID: 37906628
The scaffolding protein CARD11 is a critical mediator of antigen receptor signaling in lymphocytes. Hypomorphic (partial loss-of-function) mutations in CARD11 are associated with the development of severe atopic dermatitis, in...
2.
Loh J, Teo J, Kannan S, Verma C, Lim H, Lam K
Pharmaceutics
. 2023 Jul;
15(7).
PMID: 37513967
Invasive fungal disease is an emerging and serious public health threat globally. The expanding population of susceptible individuals, together with the rapid emergence of multidrug-resistant fungi pathogens, call for the...
3.
Teo K, Zhang S, Loh J, Lai R, Hey H, Lam K, et al.
Pharmaceutics
. 2023 May;
15(5).
PMID: 37242732
Mesenchymal stem/stromal cell (MSC) exosomes have been shown to alleviate immune dysfunction and inflammation in preclinical animal models. This therapeutic effect is attributed, in part, to their ability to promote...
4.
Loh J, Lam K
Adv Drug Deliv Rev
. 2023 Mar;
196:114775.
PMID: 36924530
Invasive fungal infection is an under recognized and emerging global health threat. Recently, the World Health Organization (WHO) released the first ever list of health-threatening fungi to guide research and...
5.
Loh J, Lam K
Rheumatol Immunol Res
. 2023 Feb;
3(3):120-127.
PMID: 36788971
Rheumatic diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), are a group of auto-inflammatory disorders associated with substantial morbidity and mortality. One...
6.
Dok3 restrains neutrophil production of calprotectin during TLR4 sensing of SARS-CoV-2 spike protein
Loh J, Teo J, Lam K
Front Immunol
. 2022 Sep;
13:996637.
PMID: 36172386
Increased neutrophils and elevated level of circulating calprotectin are hallmarks of severe COVID-19 and they contribute to the dysregulated immune responses and cytokine storm in susceptible patients. However, the precise...
7.
Loh J, Zhang B, Teo J, Lai R, Choo A, Lam K, et al.
Cytotherapy
. 2022 Feb;
24(7):711-719.
PMID: 35177337
Complements and neutrophils are two key players of the innate immune system that are widely implicated as drivers of severe COVID-19 pathogenesis, as evident by the direct correlation of respiratory...
8.
Loh J, Lee K, Lee A, Teo J, Lim H, Kim S, et al.
Cell Death Dis
. 2021 Nov;
12(11):1054.
PMID: 34743196
How pathogenesis of inflammatory bowel disease (IBD) depends on the complex interplay of host genetics, microbiome and the immune system is not fully understood. Here, we showed that Downstream of...
9.
Wang X, Lin X, Zheng Z, Lu B, Wang J, Tan A, et al.
Nat Commun
. 2021 Mar;
12(1):1914.
PMID: 33772013
Innate immunity is important for host defense by eliciting rapid anti-viral responses and bridging adaptive immunity. Here, we show that endogenous lipids released from virus-infected host cells activate lung γδ...
10.
Loh J, Teo J, Lim H, Lam K
Front Immunol
. 2020 Nov;
11:566192.
PMID: 33133079
Downstream of kinase (Dok) 3 is a member of the Dok family of adaptor proteins known to regulate signaling pathways downstream of various immunoreceptors. As Dok-3 lacks intrinsic catalytic activity,...