Jia Jia Lim
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Explore the profile of Jia Jia Lim including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
169
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Recent Articles
1.
Tran M, Lim J, Loh T, Mannering S, Rossjohn J, Reid H
J Biol Chem
. 2024 Jul;
300(9):107612.
PMID: 39074636
Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease that has a strong HLA association, where a number of self-epitopes have been implicated in disease pathogenesis. Human pancreatic islet-infiltrating...
2.
Loh T, Lim J, Jones C, Dao H, Tran M, Baker D, et al.
Nat Commun
. 2024 Jul;
15(1):6201.
PMID: 39043656
CD4 T cells recognising citrullinated self-epitopes presented by HLA-DRB1 bearing the shared susceptibility epitope (SE) are implicated in rheumatoid arthritis (RA). However, the underlying T cell receptor (TCR) determinants of...
3.
Klobuch S, Lim J, van Balen P, Kester M, de Klerk W, de Ru A, et al.
Proc Natl Acad Sci U S A
. 2022 Nov;
119(49):e2214331119.
PMID: 36442096
Human leukocyte antigen (HLA) molecules present small peptide antigens to T cells, thereby allowing them to recognize pathogen-infected and cancer cells. A central dogma over the last 50+ y is...
4.
Tran M, Faridi P, Lim J, Ting Y, Onwukwe G, Bhattacharjee P, et al.
Nat Commun
. 2021 Aug;
12(1):5110.
PMID: 34433824
HLA-DQ8, a genetic risk factor in type I diabetes (T1D), presents hybrid insulin peptides (HIPs) to autoreactive CD4+ T cells. The abundance of spliced peptides binding to HLA-DQ8 and how...
5.
Lim J, Jones C, Loh T, Ting Y, Zareie P, Loh K, et al.
Sci Immunol
. 2021 Apr;
6(58).
PMID: 33863750
Individuals expressing HLA-DR4 bearing the shared susceptibility epitope (SE) have an increased risk of developing rheumatoid arthritis (RA). Posttranslational modification of self-proteins via citrullination leads to the formation of neoantigens...
6.
Park K, Kwon M, An J, Lee J, Youn H, Lee Y, et al.
Sci Rep
. 2016 Dec;
6:39095.
PMID: 27974828
EFhd2/Swiprosin-1 is a cytoskeletal Ca-binding protein implicated in Ca-dependent cell spreading and migration in epithelial cells. EFhd2 domain architecture includes an N-terminal disordered region, a PxxP motif, two EF-hands, a...
7.
Lim J, Lee Y, Yoon S, Ly T, Kang J, Youn H, et al.
FEBS Lett
. 2016 Oct;
590(23):4402-4413.
PMID: 27714797
The interaction of the rhomboid pseudoprotease Derlin-1 and p97 is crucial for the retrotranslocation of polyubiquitinated substrates in the endoplasmic reticulum-associated degradation pathway. We report a 2.25 Å resolution structure...
8.
Lim J, Lee Y, Ly T, Kang J, Lee J, An J, et al.
Biochem J
. 2016 Jul;
473(18):2863-80.
PMID: 27407164
RHBDL4 is an active rhomboid that specifically recognizes and cleaves atypical, positively charged transmembrane endoplasmic reticulum-associated degradation (ERAD) substrates. Interaction of valosin-containing protein (p97/VCP) and RHBDL4 is crucial to retrotranslocate...
9.
Lee Y, Min C, Kim T, Song H, Lim Y, Kim D, et al.
EMBO Rep
. 2015 Sep;
16(10):1318-33.
PMID: 26341627
The mitochondrial calcium uniporter (MCU) is responsible for mitochondrial calcium uptake and homeostasis. It is also a target for the regulation of cellular anti-/pro-apoptosis and necrosis by several oncogenes and...
10.
Kim B, Cho J, Jeong P, Lee Y, Lim J, Park K, et al.
FEBS Lett
. 2015 May;
589(15):1795-801.
PMID: 26022398
Coxsackievirus B3 is the main cause of human viral myocarditis and cardiomyopathy. Virally encoded Coxsackievirus 3C protease (3C(pro)) plays an essential role in viral proliferation. Here, benserazide was discovered as...