Jessie A Turnbaugh
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Explore the profile of Jessie A Turnbaugh including associated specialties, affiliations and a list of published articles.
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14
Citations
781
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Recent Articles
1.
Alexander M, Upadhyay V, Rock R, Ramirez L, Trepka K, Puchalska P, et al.
Cell Rep
. 2024 Nov;
43(11):114891.
PMID: 39500329
Diet can protect from autoimmune disease; however, whether diet acts via the host and/or microbiome remains unclear. Here, we use a ketogenic diet (KD) as a model to dissect these...
2.
Trepka K, Kidder W, Kyaw T, Halsey T, Olson C, Ortega E, et al.
bioRxiv
. 2024 Jun;
PMID: 38895199
Dose-limiting toxicities remain a major barrier to drug development and therapy, revealing the limited predictive power of human genetics. Herein, we demonstrate the utility of a more comprehensive approach to...
3.
Alexander M, Upadhyay V, Rock R, Ramirez L, Trepka K, Puchalska P, et al.
bioRxiv
. 2023 Nov;
PMID: 37961209
Diet can protect from autoimmune disease; however, whether diet acts via the host and/or microbiome remains unclear. Here, we use a ketogenic diet (KD) as a model to dissect these...
4.
Rusu I, Mennillo E, Bain J, Li Z, Sun X, Ly K, et al.
J Clin Invest
. 2022 Jan;
132(5).
PMID: 35077396
Anti-TNF antibodies are effective for treating patients with inflammatory bowel disease (IBD), but many patients fail to respond to anti-TNF therapy, highlighting the importance of TNF-independent disease. We previously demonstrated...
5.
von Schwartzenberg R, Bisanz J, Lyalina S, Spanogiannopoulos P, Ang Q, Cai J, et al.
Nature
. 2021 Jun;
595(7866):272-277.
PMID: 34163067
Diet is a major factor that shapes the gut microbiome, but the consequences of diet-induced changes in the microbiome for host pathophysiology remain poorly understood. We conducted a randomized human...
6.
Ang Q, Alexander M, Newman J, Tian Y, Cai J, Upadhyay V, et al.
Cell
. 2020 May;
181(6):1263-1275.e16.
PMID: 32437658
Very low-carbohydrate, high-fat ketogenic diets (KDs) induce a pronounced shift in metabolic fuel utilization that elevates circulating ketone bodies; however, the consequences of these compounds for host-microbiome interactions remain unknown....
7.
Razani B, Whang M, Kim F, Nakamura M, Sun X, Advincula R, et al.
Nat Immunol
. 2020 Mar;
21(4):422-433.
PMID: 32205880
A20 is an anti-inflammatory protein that is strongly linked to human disease. Here, we find that mice expressing three distinct targeted mutations of A20's zinc finger 7 (ZF7) ubiquitin-binding motif...
8.
Bisanz J, Upadhyay V, Turnbaugh J, Ly K, Turnbaugh P
Cell Host Microbe
. 2019 Jul;
26(2):265-272.e4.
PMID: 31324413
Multiple research groups have shown that diet impacts the gut microbiome; however, variability in experimental design and quantitative assessment have made it challenging to assess the degree to which similar...
9.
Turnbaugh J, Unterberger U, Saa P, Massignan T, Fluharty B, Bowman F, et al.
J Neurosci
. 2012 Jun;
32(26):8817-30.
PMID: 22745483
Prion propagation involves a templating reaction in which the infectious form of the prion protein (PrP(Sc)) binds to the cellular form (PrP(C)), generating additional molecules of PrP(Sc). While several regions...
10.
Biasini E, Turnbaugh J, Massignan T, Veglianese P, Forloni G, Bonetto V, et al.
PLoS One
. 2012 Mar;
7(3):e33472.
PMID: 22428057
Insight into the normal function of PrP(C), and how it can be subverted to produce neurotoxic effects, is provided by PrP molecules carrying deletions encompassing the conserved central region. The...