Jessica Sudderth
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Explore the profile of Jessica Sudderth including associated specialties, affiliations and a list of published articles.
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32
Citations
2169
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Recent Articles
1.
Cai L, Hammond N, Tasdogan A, Alsamraae M, Yang C, Cameron R, et al.
Cancer Discov
. 2025 Feb;
:OF1-OF15.
PMID: 39960461
Intraoperative 13C-glucose infusions in patients with NSCLC show that tumors with high labeling of TCA cycle intermediates progress rapidly, resulting in metastasis and early death. Blocking this pathway suppresses metastasis...
2.
Bezwada D, Perelli L, Lesner N, Cai L, Brooks B, Wu Z, et al.
Nature
. 2024 Aug;
633(8031):923-931.
PMID: 39143213
Most kidney cancers are metabolically dysfunctional, but how this dysfunction affects cancer progression in humans is unknown. We infused C-labelled nutrients in over 80 patients with kidney cancer during surgical...
3.
Wang X, Menezes C, Jia Y, Xiao Y, Venigalla S, Cai F, et al.
Science
. 2024 Jun;
384(6701):eadj4301.
PMID: 38870309
Mitochondria are critical for proper organ function and mechanisms to promote mitochondrial health during regeneration would benefit tissue homeostasis. We report that during liver regeneration, proliferation is suppressed in electron...
4.
Cai L, Vu H, Gu W, Chen H, Franklin J, Abou Haidar L, et al.
bioRxiv
. 2024 Jan;
PMID: 38168314
Metabolomic profiling is instrumental in understanding the systemic and cellular impact of inborn errors of metabolism (IEMs), monogenic disorders caused by pathogenic genomic variants in genes involved in metabolism. This...
5.
Huffman K, Li L, Carstens R, Park H, Girard L, Avila K, et al.
Front Oncol
. 2023 Apr;
13:1025443.
PMID: 37035141
The glucocorticoid receptor (GR) is an important anti-cancer target in lymphoid cancers but has been understudied in solid tumors like lung cancer, although glucocorticoids are often given with chemotherapy regimens...
6.
Bezwada D, Lesner N, Brooks B, Vu H, Wu Z, Cai L, et al.
bioRxiv
. 2023 Feb;
PMID: 36798172
Most kidney cancers display evidence of metabolic dysfunction but how this relates to cancer progression in humans is unknown. We used a multidisciplinary approach to infuse C-labeled nutrients during surgical...
7.
Pachnis P, Wu Z, Faubert B, Tasdogan A, Gu W, Shelton S, et al.
Sci Adv
. 2022 Aug;
8(35):eabn9550.
PMID: 36044570
In mice and humans with cancer, intravenous C-glucose infusion results in C labeling of tumor tricarboxylic acid (TCA) cycle intermediates, indicating that pyruvate oxidation in the TCA cycle occurs in...
8.
Parida P, Marquez-Palencia M, Kaushik A, Kim K, Nair V, Sudderth J, et al.
STAR Protoc
. 2022 May;
3(2):101345.
PMID: 35496802
Analyzing the metabolic dependencies of tumor cells is vital for cancer diagnosis and treatment. Here, we describe a protocol for C-stable glucose and glutamine isotope tracing in mice HER2+ breast...
9.
MacPherson S, Keyes S, Kilgour M, Smazynski J, Chan V, Sudderth J, et al.
Mol Ther Methods Clin Dev
. 2022 Mar;
24:380-393.
PMID: 35284590
expansion conditions used to generate T cells for immunotherapy are thought to adopt metabolic phenotypes that impede therapeutic efficacy . The comparison of five different culture media used for clinical...
10.
Parida P, Marquez-Palencia M, Nair V, Kaushik A, Kim K, Sudderth J, et al.
Cell Metab
. 2022 Jan;
34(1):90-105.e7.
PMID: 34986341
HER2+ breast cancer patients are presented with either synchronous (S-BM), latent (Lat), or metachronous (M-BM) brain metastases. However, the basis for disparate metastatic fitness among disseminated tumor cells of similar...