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Jessica R Sheldon

Explore the profile of Jessica R Sheldon including associated specialties, affiliations and a list of published articles. Areas
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Articles 22
Citations 724
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Recent Articles
1.
Wise A, TenBarge E, Mendonca J, Mennen E, McDaniel S, Reber C, et al.
Cell Host Microbe . 2025 Feb; 33(3):341-357.e9. PMID: 40020664
Neutrophils induce oxidative stress, creating a harsh phagosomal environment. However, Staphylococcus aureus can survive these conditions, requiring neutrophils to deploy mechanisms that sense bacterial persistence. We find that staphylococcal lactate...
2.
Sheldon J, Himmel L, Kunkle D, Monteith A, Maloney K, Skaar E
PLoS Pathog . 2022 Sep; 18(9):e1010809. PMID: 36054235
Acinetobacter baumannii is an opportunistic pathogen and an emerging global health threat. Within healthcare settings, major presentations of A. baumannii include bloodstream infections and ventilator-associated pneumonia. The increased prevalence of...
3.
Batko I, Flannagan R, Guariglia-Oropeza V, Sheldon J, Heinrichs D
J Bacteriol . 2021 Oct; 203(24):e0045821. PMID: 34606375
Respiration-deficient Staphylococcus aureus small-colony variants (SCVs) frequently cause persistent infections, which necessitates they acquire iron, yet how SCVs obtain iron remains unknown. To address this, we created a stable mutant...
4.
Sheldon J, Skaar E
PLoS Pathog . 2020 Oct; 16(10):e1008995. PMID: 33075115
Acinetobacter baumannii is an emerging pathogen that poses a global health threat due to a lack of therapeutic options for treating drug-resistant strains. In addition to acquiring resistance to last-resort...
5.
Le N, Peters K, Espaillat A, Sheldon J, Gray J, Di Venanzio G, et al.
Sci Adv . 2020 Aug; 6(30):eabb5614. PMID: 32832672
Peptidoglycan (PG) is essential in most bacteria. Thus, it is often targeted by various assaults, including interbacterial attacks via the type VI secretion system (T6SS). Here, we report that the...
6.
Perry W, Spraggins J, Sheldon J, Grunenwald C, Heinrichs D, Cassat J, et al.
Proc Natl Acad Sci U S A . 2019 Oct; 116(44):21980-21982. PMID: 31611408
Siderophores, iron-scavenging small molecules, are fundamental to bacterial nutrient metal acquisition and enable pathogens to overcome challenges imposed by nutritional immunity. Multimodal imaging mass spectrometry allows visualization of host-pathogen iron...
7.
Sheldon J, Skaar E
Curr Opin Immunol . 2019 May; 60:1-9. PMID: 31063946
Transition metal ions are essential to bacterial pathogens and their hosts alike but are harmful in excess. In an effort to curtail the replication of intracellular bacteria, host phagocytes exploit...
8.
Childress E, Garrison A, Sheldon J, Skaar E, Lindsley C
J Org Chem . 2019 May; 84(10):6459-6464. PMID: 31039303
Here, we report the first total synthesis of hinduchelins A-D, a family of nontoxic catechol derivatives from Streptoalloteichus hindustanus, possessing a druglike chemotype and modest iron-chelating ability. A concise synthesis...
9.
Palmer L, Green E, Sheldon J, Skaar E
Methods Mol Biol . 2019 Feb; 1946:289-305. PMID: 30798564
Acinetobacter baumannii is a Gram-negative opportunistic pathogen and a leading cause of ventilator-associated pneumonia. Murine models of A. baumannii lung infection allow researchers to experimentally assess A. baumannii virulence and...
10.
Goncheva M, Flannagan R, Sterling B, Laakso H, Friedrich N, Kaiser J, et al.
Nat Commun . 2019 Feb; 10(1):775. PMID: 30770821
Staphylococcus aureus is a significant cause of human infection. Here, we demonstrate that mutations in the transcriptional repressor of purine biosynthesis, purR, enhance the pathogenic potential of S. aureus. Indeed,...