Jessica N Lancaster
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Explore the profile of Jessica N Lancaster including associated specialties, affiliations and a list of published articles.
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14
Citations
171
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Recent Articles
1.
Zhu Y, Guo S, Ravichandran D, Ramanathan A, Sobczak M, Sacco A, et al.
Adv Healthc Mater
. 2024 Nov;
14(1):e2402571.
PMID: 39498750
3D printing, also known as additive manufacturing, holds immense potential for rapid prototyping and customized production of functional health-related devices. With advancements in polymer chemistry and biomedical engineering, polymeric biomaterials...
2.
Fisher J, Adan-Barrientos I, Kumar N, Lancaster J
Aging Cell
. 2024 Mar;
23(6):e14140.
PMID: 38481058
Weakened germinal center responses by the aged immune system result in diminished immunity against pathogens and reduced efficacy of vaccines. Prolonged contacts between activated B cells and CD4 T cells...
3.
Lancaster J
Semin Immunol
. 2023 Aug;
70:101817.
PMID: 37572552
The secondary lymphoid organs (SLOs) undergo structural changes with age, which correlates with diminishing immune responses against infectious disease. A growing body of research suggests that the aged tissue microenvironment...
4.
Kwok T, Medovich S, Silva-Junior I, Brown E, Haug J, Barrios M, et al.
Front Aging
. 2022 Jul;
3:838943.
PMID: 35821826
The decreased proportion of antigen-inexperienced, naïve T cells is a hallmark of aging in both humans and mice, and contributes to reduced immune responses, particularly against novel and re-emerging pathogens....
5.
Lancaster J, Keatinge-Clay D, Srinivasan J, Li Y, Selden H, Nam S, et al.
Aging Cell
. 2022 May;
21(6):e13624.
PMID: 35561351
One of the earliest hallmarks of immune aging is thymus involution, which not only reduces the number of newly generated and exported T cells, but also alters the composition and...
6.
Srinivasan J, Lancaster J, Singarapu N, Hale L, Ehrlich L, Richie E
Front Immunol
. 2021 May;
12:676236.
PMID: 33968086
Thymic epithelial cells (TECs) and hematopoietic antigen presenting cells (HAPCs) in the thymus microenvironment provide essential signals to self-reactive thymocytes that induce either negative selection or generation of regulatory T...
7.
Singarapu N, Ma K, Reeh K, Shen J, Lancaster J, Yi S, et al.
Sci Rep
. 2018 Sep;
8(1):14335.
PMID: 30254371
Thymic epithelial cells (TEC) are essential for thymocyte differentiation and repertoire selection. Despite their indispensable role in generating functional T cells, the molecular mechanisms that orchestrate TEC development from endodermal...
8.
Thyagarajan H, Lancaster J, Lira S, Ehrlich L
PLoS One
. 2018 Jul;
13(7):e0200765.
PMID: 30024927
Following positive selection, thymocytes migrate into the medulla where they encounter diverse self-antigens that induce central tolerance. Thymocytes expressing T cell receptors (TCRs) with high affinity for self-antigens displayed by...
9.
Hu Z, Lancaster J, Ehrlich L, Muller P
J Appl Stat
. 2018 Feb;
45(4):697-713.
PMID: 29403142
The detection of T cell activation is critical in many immunological assays. However, detecting T cell activation in live tissues remains a challenge due to highly noisy data. We developed...
10.
Lancaster J, Li Y, Ehrlich L
Trends Immunol
. 2017 Nov;
39(2):86-98.
PMID: 29162323
As they differentiate, thymocytes encounter spatially restricted cues critical for differentiation and selection of a functional, self-tolerant T cell repertoire. Sequential migration of developing T cells through distinct thymic microenvironments...