Jessica G K OBrien
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Explore the profile of Jessica G K OBrien including associated specialties, affiliations and a list of published articles.
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3
Citations
23
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Recent Articles
1.
OBrien J, Conway L, Ramaraj P, Jadhav A, Jin J, Dutra J, et al.
Chem Sci
. 2024 Sep;
PMID: 39246352
Dialkyldiazirines have emerged as a photo-reactive group of choice for interactome mapping in live cell experiments. Upon irradiation, 'linear' dialkyldiazirines produce dialkylcarbenes which are susceptible to both intramolecular reactions and...
2.
OBrien J, Jemas A, Asare-Okai P, Am Ende C, Fox J
Org Lett
. 2020 Dec;
22(24):9415-9420.
PMID: 33259213
Dialkyldiazirines have emerged as reagents of choice for biological photoaffinity labeling studies. The mechanism of crosslinking has dramatic consequences for biological applications where instantaneous labeling is desirable, as carbene insertions...
3.
OBrien J, Chintala S, Fox J
J Org Chem
. 2017 Nov;
83(14):7500-7503.
PMID: 29171257
The cyclooctyne BCN and the trans-cyclooctene s-TCO are widely used in bioorthogonal chemistry. A bottleneck for their synthesis had been a poorly selective cyclopropanation with ethyl diazoacetate. Here, we describe...