Jesse C Cochrane
Overview
Explore the profile of Jesse C Cochrane including associated specialties, affiliations and a list of published articles.
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13
Citations
614
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Recent Articles
1.
Jaensch E, Zhu J, Cochrane J, Marr S, Oei T, Damle M, et al.
Mol Cell
. 2021 Oct;
81(22):4677-4691.e8.
PMID: 34637753
The CBX family of proteins is central to proper mammalian development via key roles in Polycomb-mediated maintenance of repression. CBX proteins in differentiated lineages have chromatin compaction and phase separation...
2.
Jegu T, Blum R, Cochrane J, Yang L, Wang C, Gilles M, et al.
Nat Struct Mol Biol
. 2019 Jan;
26(2):96-109.
PMID: 30664740
The noncoding RNA Xist recruits silencing factors to the inactive X chromosome (Xi) and facilitates re-organization of Xi structure. Here, we examine the mouse epigenomic landscape of Xi and assess...
3.
Royer L, Herzog J, Kenny K, Tzvetkova B, Cochrane J, Marr 2nd M, et al.
J Biol Chem
. 2018 Aug;
293(38):14798-14811.
PMID: 30072381
Ca/calmodulin-dependent protein kinase II (CaMKII) is a well-characterized, abundant protein kinase that regulates a diverse set of functions in a tissue-specific manner. For example, in heart muscle, CaMKII regulates Ca...
4.
Ardehali M, Anselmo A, Cochrane J, Kundu S, Sadreyev R, Kingston R
Mol Cell
. 2017 Nov;
68(5):872-884.e6.
PMID: 29153392
Polycomb repressive complex 2 (PRC2-EZH2) methylates histone H3 at lysine 27 (H3K27) and is required to maintain gene repression during development. Misregulation of PRC2 is linked to a range of...
5.
Iwase S, Xiang B, Ghosh S, Ren T, Lewis P, Cochrane J, et al.
Nat Struct Mol Biol
. 2011 Jun;
18(7):769-76.
PMID: 21666679
ATR-X (alpha-thalassemia/mental retardation, X-linked) syndrome is a human congenital disorder that causes severe intellectual disabilities. Mutations in the ATRX gene, which encodes an ATP-dependent chromatin-remodeler, are responsible for the syndrome....
6.
Antonioli A, Cochrane J, Lipchock S, Strobel S
RNA
. 2010 Feb;
16(4):762-8.
PMID: 20145044
The kink turn (K-turn) is an RNA structural motif found in many biologically significant RNAs. While most examples of the K-turn have a similar fold, the crystal structure of the...
7.
Cochrane J, Lipchock S, Smith K, Strobel S
Biochemistry
. 2009 Feb;
48(15):3239-46.
PMID: 19228039
The glmS ribozyme is the first naturally occurring catalytic RNA that relies on an exogenous, nonnucleotide cofactor for reactivity. From a biochemical perspective, the glmS ribozyme derived from Bacillus anthracis...
8.
Cochrane J, Strobel S
Acc Chem Res
. 2008 Jul;
41(8):1027-35.
PMID: 18652494
[Structure: see text]. Five naturally occurring nucleolytic ribozymes have been identified: the hammerhead, hairpin, glmS, hepatitis delta virus (HDV), and Varkud satellite (VS) ribozymes. All of these RNA enzymes catalyze...
9.
Cochrane J, Strobel S
RNA
. 2008 Apr;
14(6):993-1002.
PMID: 18430893
The recently identified glmS ribozyme revealed that RNA enzymes, like protein enzymes, are capable of using small molecules as catalytic cofactors to promote chemical reactions. Flavin mononucleotide (FMN), S-adenosyl methionine...
10.
Cochrane J, Strobel S
Curr Protoc Nucleic Acid Chem
. 2008 Apr;
Chapter 6:Unit 6.9.
PMID: 18428931
Nucleotide analog interference mapping (NAIM) can be used to simultaneously, yet individually, identify structurally or catalytically important functional groups within an RNA molecule. Phosphorothioate-tagged nucleotides and nucleotide analogs are randomly...