Jerzy Ciarkowski
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Explore the profile of Jerzy Ciarkowski including associated specialties, affiliations and a list of published articles.
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30
Citations
158
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Recent Articles
1.
Zurawa-Janicka D, Wenta T, Jarzab M, Skorko-Glonek J, Glaza P, Gieldon A, et al.
Arch Biochem Biophys
. 2017 Apr;
621:6-23.
PMID: 28396256
Human HtrA1-4 proteins belong to the HtrA family of evolutionarily conserved serine proteases and function as important modulators of many physiological processes, including maintenance of mitochondrial homeostasis, cell signaling and...
2.
Gieldon A, Zurawa-Janicka D, Jarzab M, Wenta T, Golik P, Dubin G, et al.
PLoS One
. 2016 Aug;
11(8):e0161526.
PMID: 27571206
HtrA2(Omi) protease controls protein quality in mitochondria and plays a major role in apoptosis. Its HtrA2S306A mutant (with the catalytic serine routinely disabled for an X-ray study to avoid self-degradation)...
3.
Lubecka E, Sikorska E, Sobolewski D, Prahl A, Slaninova J, Ciarkowski J
Biopolymers
. 2016 Feb;
106(3):245-59.
PMID: 26916937
Deamination of vasopressin (AVP) enhances its antidiuretic activity. Moreover, introduction of D-Arg8 instead of its L enantiomer in deamino-vasopressin (dAVP) results in an extremely potent and selective antidiuretic agonist -...
4.
Jarzab M, Wenta T, Zurawa-Janicka D, Polit A, Gieldon A, Wysocka M, et al.
Biochim Biophys Acta
. 2015 Dec;
1864(3):283-296.
PMID: 26702898
HtrA2(Omi) protease is involved in the maintenance of mitochondrial homeostasis and stimulation of apoptosis as well as in development of cancer and neurodegenerative disorders. The protein is a homotrimer whose...
5.
Lubecka E, Sikorska E, Sobolewski D, Prahl A, Slaninova J, Ciarkowski J
Eur Biophys J
. 2015 Aug;
44(8):727-43.
PMID: 26290060
We describe the synthesis, pharmacological properties, and structures of antidiuretic agonists, arginine vasopressin (AVP) and [D-Arg(8)]-vasopressin (DAVP), and their inverso analogues. The structures of the peptides are studied based on...
6.
Maszota M, Karska N, Spodzieja M, Ciarkowski J, Kolodziejczyk A, Rodziewicz-Motowidlo S, et al.
J Mol Recognit
. 2015 Mar;
28(7):413-26.
PMID: 25736604
Serum amyloid A (SAA) is a multifunctional acute-phase protein whose concentration in serum increases markedly following a number of chronic inflammatory and neoplastic diseases. Prolonged high SAA level may give...
7.
Figaj D, Gieldon A, Polit A, Sobiecka-Szkatula A, Koper T, Denkiewicz M, et al.
J Biol Chem
. 2014 Apr;
289(22):15880-93.
PMID: 24737328
Bacterial HtrAs are serine proteases engaged in extracytoplasmic protein quality control and are required for the virulence of several pathogenic species. The proteolytic activity of HtrA (DegP) from Escherichia coli,...
8.
Lubecka E, Sikorska E, Marcinkowska A, Ciarkowski J
J Pept Sci
. 2014 Mar;
20(6):406-14.
PMID: 24644276
Two glycosylated peptides have been studied using NMR spectroscopy supported by molecular modeling. Peptide I is an oxytocin (OT) analogue in which glutamine 4 was replaced by serine with attached...
9.
Zurawa-Janicka D, Jarzab M, Polit A, Skorko-Glonek J, Lesner A, Gitlin A, et al.
Cell Stress Chaperones
. 2012 Aug;
18(1):35-51.
PMID: 22851136
HtrA2(Omi), belonging to the high-temperature requirement A (HtrA) family of stress proteins, is involved in the maintenance of mitochondrial homeostasis and in the stimulation of apoptosis, as well as in...
10.
Lubecka E, Ciarkowski J, Prahl A, Sikorska E
Chem Biol Drug Des
. 2012 Feb;
79(6):1033-42.
PMID: 22321057
In this paper, we investigated the structure-activity relationship of two vasopressin analogues, [Cpa(1),(L-1-Nal)(2) ]AVP (I) and [Cpa(1),(D-Nal)(2) ]AVP (II) by NMR spectroscopy and molecular modeling. Both peptides exhibit antioxytocic and...