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Jerrold S Levine

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Recent Articles
1.
Sinha U, Setty S, Pilon C, Brown J, Ruiz M, Ren G, et al.
Br J Haematol . 2025 Jan; PMID: 39748216
We describe a patient with sickle cell disease (SCD) and elevated antiphospholipid antibodies (aPL) who developed multi-organ failure resembling catastrophic antiphospholipid syndrome. Autoimmune screening revealed several autoantibodies characteristic of systemic...
2.
Iglesias J, Okoh N, Ang S, Rodriguez C, Chia J, Levine J
J Cardiovasc Dev Dis . 2024 Mar; 11(3). PMID: 38535116
Congestive heart failure (CHF) is associated with significant morbidity and mortality. There has been renewed interest in using thrombo-inflammatory markers as prognostic tools in patients with CHF. To determine if...
3.
Kmetova K, Lonina E, Yalavarthi S, Levine J, Hoy C, Sarosh C, et al.
Clin Immunol . 2023 Aug; 255:109714. PMID: 37527733
Beta-2 glycoprotein I (βGPI) is a phospholipid-binding plasma protein and prominent autoantigen in antiphospholipid syndrome (APS). Here, we tested the hypothesis that βGPI might bind to not only phospholipids, but...
4.
Iglesias J, Vassallo A, Ilagan J, Ang S, Udongwo N, Mararenko A, et al.
Biomedicines . 2023 Mar; 11(3). PMID: 36979824
Background: Acute kidney injury (AKI) is a common complication in patients with severe COVID-19. Methods: We retrospectively reviewed 249 patients admitted to an intensive care unit (ICU) during the first...
5.
Rivera C, Srisuwananukorn A, Bajwa R, Gordeuk V, Rauch J, Levine J, et al.
EJHaem . 2023 Feb; 4(1):211-215. PMID: 36819151
Although a higher prevalence of antiphospholipid autoantibodies (aPL) has been observed in some cohorts of sickle cell disease (SCD) patients, the clinical risk factors for the development of aPL and...
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Iglesias J, Vassallo A, Liesenfeld O, Levine J, Patel V, Sullivan J, et al.
J Pers Med . 2020 Dec; 11(1). PMID: 33374697
Background: Retrospective analysis of the transcriptomic host response in sepsis has demonstrated that sepsis can be separated into three endotypes-inflammatory (IE), adaptive (AE), and coagulopathic (CE), which have demonstrated prognostic...
8.
Li F, Bahnson E, Wilder J, Siletzky R, Hagaman J, Nickekeit V, et al.
Redox Biol . 2020 Mar; 32:101504. PMID: 32182573
Renal ischemia/reperfusion injury (IRI) is a leading cause of acute kidney injury (AKI), a potentially fatal syndrome characterized by a rapid decline in kidney function. Excess production of superoxide contributes...
9.
Salem D, Subang R, Pernet E, Divangahi M, Pineau C, Cayrol R, et al.
Immunol Cell Biol . 2019 Jun; 97(9):799-814. PMID: 31187539
Systemic lupus erythematosus (SLE) is characterized by the development of autoantibodies against diverse self-antigens with damage to multiple organs. Immunization with the SLE autoantigen β -glycoprotein I (β GPI) and...
10.
Levine J, Ucker D
Adv Protein Chem Struct Biol . 2019 May; 116:1-90. PMID: 31036289
Of the roughly one million cells per second dying throughout the body, the vast majority dies by apoptosis, the predominant form of regulated cell death in higher organisms. Long regarded...